Genetic association of interleukin-4, interleukin-10, and transforming growth factor-β gene polymorphism with allograft function in renal transplant patients

被引：17

作者：

Amirzargar, M. ^{[1
]}

Yavangi, M. ^{[1
]}

Basiri, A. ^{[1
]}

Moghadam, S. H. ^{[1
]}

Khosravi, F. ^{[1
]}

Solgi, G. ^{[1
]}

Gholiaf, M. ^{[1
]}

Khoshkho, F. ^{[1
]}

Dadaras, F. ^{[1
]}

Mahmmodi, M. ^{[1
]}

Ansaripour, B. ^{[1
]}

Amirzargar, A. ^{[1
]}

Nikbin, B. ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Immunogenet Res Ctr, Tehran, Iran

来源：

TRANSPLANTATION PROCEEDINGS | 2007年 / 39卷 / 04期

关键词：

D O I：

10.1016/j.transproceed.2007.03.054

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Despite advances in immunosuppressive therapy in the past decade, allograft rejection remains the primary cause for kidney graft failure. Cytokines are known to be important mediators in renal allograft outcome. The aim of the present study was to ascertain whether interleukin (IL)-4, IL-10, and transforming growth factor (TGF)-beta cytokine gene polymorphisms contributed to kidney graft outcome. We evaluated single nucleotide polymorphism in IL-4 (-1098G/T, -590C/T, -33C/T), IL-10 (-1082A/G, -819C/T, -592A/C), and TGF-beta (codon 10 and 25) in 100 renal transplant recipients and 139 normal healthy control using polymerase chain reactions based on sequence-specific primers. Recipients were clinically characterized as rejection episode (RE) versus stable graft function (SGF). The results showed the frequencies of IL-4 -33 T allele in the RE, SGF, and control group to be 7%, 73%, and 28%, respectively. IL-10 -592 A allele frequency was 39% in RE, 26% in SGF, and 28% in the control group. TGF-beta codon 10 T allele was 39% in RE, 35% in SGF, and 53% in control group. In conclusion, this study suggested that some cytokine gene alleles reflected SGF among kidney transplant recipients.

引用

页码：954 / 957

页数：4

共 16 条

[1] Cytokine gene polymorphisms and risks of acute rejection and delayed graft function after kidney transplantation [J].

Alakulppi, NS ;

Kyllönen, LE ;

Jäntti, VT ;

Matinlauri, IH ;

Partanen, J ;

Salmela, KT ;

Laine, JT .

TRANSPLANTATION, 2004, 78 (10) :1422-1428

[2]

Filippo SD, 2005, HUM IMMUNOL, V66, P133

[3] Role of codon 10 and codon 25 polymorphisms on TGF-β1 gene expression and protein synthesis in stable renal allograft recipients [J].

Guo, Z ;

Binswanger, U ;

Knoflach, A .

TRANSPLANTATION PROCEEDINGS, 2002, 34 (07) :2904-2906

[4] Cytokines and chemokine gene expression in human kidney transplantation [J].

Hribova, P ;

Kotsch, K ;

Brabcova, I ;

Vitko, S ;

Volk, HD ;

Lacha, J .

TRANSPLANTATION PROCEEDINGS, 2005, 37 (02) :760-763

[5] Effect of cytokines and chemokines (TGF-β, TNF-α, IL-6, IL-10, MCP-1 RANTES) gene polymorphisms in kidney recipients on posttransplantation outcome:: Influence of donor-recipient MATCH [J].

Lacha, J ;

Hribova, P ;

Kotsch, K ;

Brabcova, I ;

Bartosova, K ;

Volk, HD ;

Vitko, S .

TRANSPLANTATION PROCEEDINGS, 2005, 37 (02) :764-766

[6] Influence of recipient and donor IL-1α, IL-4, and TNFα genotypes on the incidence of acute renal allograft rejection [J].

Lee, H ;

Clark, B ;

Gooi, HC ;

Stoves, J ;

Newstead, CG .

JOURNAL OF CLINICAL PATHOLOGY, 2004, 57 (01) :101-103

[7] Impact of donor and recipient cytokine genotypes on renal allograft outcome [J].

Ligeiro, D ;

Sancho, MR ;

Papoila, A ;

Barradinhas, AM ;

Almeida, A ;

Calao, S ;

Machado, D ;

Nolasco, F ;

Guerra, J ;

Sampaio, MJ ;

Trindade, H .

TRANSPLANTATION PROCEEDINGS, 2004, 36 (04) :827-829

[8] Genetic association of interleukin-1β and receptor antagonist (IL-1 Ra) gene polymorphism with allograft function in renal transplant patients [J].

Manchanda, Parmeet Kaur ;

Bid, Hemant Kumar ;

Kumar, Anant ;

Mittal, Rama Devi .

TRANSPLANT IMMUNOLOGY, 2006, 15 (04) :289-296

[9] Combined analysis of cytokine genotype polymorphism and the level of expression with allograft function in African-American renal transplant patients [J].

McDaniel, DO ;

Barber, WH ;

Nguyan, C ;

Rhodes, SW ;

May, WL ;

McDaniel, LS ;

Vig, PJS ;

Jemeson, LL ;

Butkus, DE .

TRANSPLANT IMMUNOLOGY, 2003, 11 (01) :107-119

[10]

MILLER SA, 1988, NUCLEIC ACIDS RES, V16, P12

← 1 2 →