Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin

被引：26

作者：

Kronenberg, Golo ^{[1
]}

Mosienko, Valentina ^{[2
,4
]}

Gertz, Karen ^{[3
]}

Alenina, Natalia ^{[2
]}

Hellweg, Rainer ^{[1
]}

Klempin, Friederike ^{[2
]}

机构：

[1] Charite, Campus Charite Mitte, Dept Psychiat & Psychotherapy, D-13353 Berlin, Germany

[2] Max Delbruck Ctr Mol Med MDC, Res Team Cardiovasc Hormones & Peptides, Robert Roessle Str 10, D-13125 Berlin, Germany

[3] Charite, Dept Neurol, D-13353 Berlin, Germany

[4] Univ Bristol, Sch Physiol & Pharmacol, Bristol, Avon, England

来源：

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | 2016年 / 266卷 / 03期

关键词：

BDNF; SERT; TPH2; Serotonin; Depression; Antidepressant; MESSENGER-RNA; RAT HIPPOCAMPUS; TRANSPORTER; DEPRESSION; NEUROGENESIS; EXPRESSION; 3,4-METHYLENEDIOXYMETHAMPHETAMINE; NEUROTRANSMISSION; DEFICIENT; TURNOVER;

D O I：

10.1007/s00406-015-0611-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The interplay between BDNF signaling and the serotonergic system remains incompletely understood. Using a highly sensitive enzyme-linked immunosorbent assay, we studied BDNF concentrations in hippocampus and cortex of two mouse models of altered serotonin signaling: tryptophan hydroxylase (Tph)2-deficient (Tph2 (-/-)) mice lacking brain serotonin and serotonin transporter (SERT)-deficient (SERT-/-) mice lacking serotonin re-uptake. Surprisingly, hippocampal BDNF was significantly elevated in Tph2 (-/-) mice, whereas no significant changes were observed in SERT-/- mice. Furthermore, BDNF levels were increased in the prefrontal cortex of Tph2 (-/-) but not of SERT-/- mice. Our results emphasize the interaction between serotonin signaling and BDNF. Complete lack of brain serotonin induces BDNF expression.

引用

页码：281 / 284

页数：4

共 36 条

[1] The role of serotonin in adult hippocampal neurogenesis [J].

Alenina, Natalia ;

Klempin, Friederike .

BEHAVIOURAL BRAIN RESEARCH, 2015, 277 :49-57

[2] Growth retardation and altered autonomic control in mice lacking brain serotonin [J].

Alenina, Natalia ;

Kikic, Dana ;

Todiras, Mihail ;

Mosienko, Valentina ;

Qadri, Fatimunnisa ;

Plehm, Ralph ;

Boye, Philipp ;

Vilianovitch, Larissa ;

Sohr, Reinhard ;

Tenner, Katja ;

Hoertnagl, Heide ;

Bader, Michael .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (25) :10332-10337

[3] Neurotrophin trafficking by anterograde transport [J].

Altar, CA ;

DiStefano, PS .

TRENDS IN NEUROSCIENCES, 1998, 21 (10) :433-437

[4] Altered brain serotonin homeostasis and locomotor insensitivity to 3,4-methylenedioxymethamphetamine ("ecstasy") in serotonin transporter-deficient mice [J].

Bengel, D ;

Murphy, DL ;

Andrews, AM ;

Wichems, CH ;

Feltner, D ;

Heils, A ;

Mössner, R ;

Westphal, H ;

Lesch, KP .

MOLECULAR PHARMACOLOGY, 1998, 53 (04) :649-655

[5] Influence of brain-derived neurotrophic factor (BDNF) on serotonin neurotransmission in the hippocampus of adult rodents [J].

Benmansour, Saloua ;

Deltheil, Thierry ;

Piotrowski, Jonathan ;

Nicolas, Lorelei ;

Reperant, Christelle ;

Gardier, Alain M. ;

Frazer, Alan ;

David, Denis J. .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2008, 587 (1-3) :90-98

[6] Exposure to early life stress regulates Bdnf expression in SERT mutant rats in an anatomically selective fashion [J].

Calabrese, Francesca ;

van der Doelen, Rick H. A. ;

Guidotti, Gianluigi ;

Racagni, Giorgio ;

Kozicz, Tamas ;

Homberg, Judith R. ;

Riva, Marco A. .

JOURNAL OF NEUROCHEMISTRY, 2015, 132 (01) :146-154

[7] Identifying molecular substrates in a mouse model of the serotonin transporter x environment risk factor for anxiety and depression [J].

Carola, Valeria ;

Frazzetto, Giovanni ;

Pascucci, Tiziana ;

Audero, Enrica ;

Puglisi-Allegra, Stefano ;

Cabib, Simona ;

Lesch, Klaus-Peter ;

Gross, Cornelius .

BIOLOGICAL PSYCHIATRY, 2008, 63 (09) :840-846

[8] THE IMPACT OF ENVIRONMENTAL ENRICHMENT ON SEX-SPECIFIC NEUROCHEMICAL CIRCUITRIES - EFFECTS ON BRAIN-DERIVED NEUROTROPHIC FACTOR AND THE SEROTONERGIC SYSTEM [J].

Chourbaji, S. ;

Hoertnagl, H. ;

Molteni, R. ;

Riva, M. A. ;

Gass, P. ;

Hellweg, R. .

NEUROSCIENCE, 2012, 220 :267-276

[9] ESSENTIAL ROLE OF BRAIN-DERIVED NEUROTROPHIC FACTOR IN THE REGULATION OF SEROTONIN TRANSMISSION IN THE BASOLATERAL AMYGDALA [J].

Daftary, S. S. ;

Calderon, G. ;

Rios, M. .

NEUROSCIENCE, 2012, 224 :125-134

[10] Effects of the antidepressant fluoxetine on the subcellular localization of 5-HT1A receptors and SERT [J].

Descarries, Laurent ;

Riad, Mustaph .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2012, 367 (1601) :2416-2425

← 1 2 3 4 →