Towards "bionic'' proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics

被引：17

作者：

Burslem, George M. ^{[1
,2
]}

Kyle, Hannah F. ^{[2
,3
]}

Breeze, Alexander L. ^{[2
,3
,4
]}

Edwards, Thomas A. ^{[2
,3
]}

Nelson, Adam ^{[1
,2
]}

Warriner, Stuart L. ^{[1
,2
]}

Wilson, Andrew J. ^{[1
,2
]}

机构：

[1] Univ Leeds, Sch Chem, Woodhouse Lane, Leeds LS2 9JT, W Yorkshire, England

[2] Univ Leeds, Astbury Ctr Struct Mol Biol, Woodhouse Lane, Leeds LS2 9JT, W Yorkshire, England

[3] Univ Leeds, Fac Biol Sci, Sch Mol & Cellular Biol, Woodhouse Lane, Leeds LS2 9JT, W Yorkshire, England

[4] AstraZeneca R&D, Discovery Sci, Alderley Pk SK10 4TG, Cheshire, England

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 31期

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会; 欧洲研究理事会;

关键词：

STRUCTURAL BASIS; INHIBITORS; PEPTIDE; PROSTHESIS; MODULATION; DOMAIN;

D O I：

10.1039/c6cc01812b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Using the HIF-1 alpha transcription factor as a model, this manuscript illustrates how an extended sequence of alpha-amino acids in a polypeptide can be replaced with a non-natural topographical mimic of an alpha-helix comprised from an aromatic oligoamide. The resultant hybrid is capable of reproducing the molecular recognition profile of the p300 binding sequence of HIF-1 alpha from which it is derived.

引用

收藏

页码：5421 / 5424

页数：4

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