Targeted insertion of an expanded CAG trinucleotide repeat into the mouse Sca1 locus.

被引：0
|
作者：
Lorenzetti, D
Matzuk, M
Guo, Q
Orr, H
Zoghbi, HY
机构：
[1] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA
[3] Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA
[4] Univ Minnesota, Inst Human Genet, Minneapolis, MN 55455 USA
[5] Howard Hughes Med Inst, Houston, TX 77030 USA
来源：
AMERICAN JOURNAL OF HUMAN GENETICS | 1997年 / 61卷 / 04期
关键词：
D O I：
暂无
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
1834
引用
收藏
页码：A314 / A314
页数：1
相关论文
共 50 条
  • [1] Repeat instability and motor incoordination in mice with a targeted expanded CAG repeat in the Sca1 locus
    Lorenzetti, D
    Watase, K
    Xu, BS
    Matzuk, MM
    Orr, HT
    Zoghbi, HY
    HUMAN MOLECULAR GENETICS, 2000, 9 (05) : 779 - 785
  • [2] SCA1 TRANSGENIC MICE - A MODEL FOR NEURODEGENERATION CAUSED BY AN EXPANDED CAG TRINUCLEOTIDE REPEAT
    BURRIGHT, EN
    CLARK, HB
    SERVADIO, A
    MATILLA, T
    FEDDERSEN, RM
    YUNIS, WS
    DUVICK, LA
    ZOGHBI, HY
    ORR, HT
    CELL, 1995, 82 (06) : 937 - 948
  • [3] Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1
    Hubert, Leroy, Jr.
    Lin, Yunfu
    Dion, Vincent
    Wilson, John H.
    HUMAN MOLECULAR GENETICS, 2011, 20 (24) : 4822 - 4830
  • [4] A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration
    Watase, K
    Weeber, EJ
    Xu, BS
    Antalffy, B
    Yuva-Paylor, L
    Hashimoto, K
    Kano, M
    Atkinson, R
    Sun, YL
    Armstrong, DL
    Sweatt, JD
    Orr, HT
    Paylor, R
    Zoghbi, HY
    NEURON, 2002, 34 (06) : 905 - 919
  • [5] Is the 31 CAG repeat allele of the spinocerebellar ataxia 1 (SCA1) gene locus non-specifically associated with trinucleotide expansion diseases?
    Savic, D
    Topisirovic, I
    Keckarevic, M
    Keckarevic, D
    Major, T
    Culjkovic, B
    Stojkovic, O
    Rakocevic-Stojanovic, V
    Mladenovic, J
    Todorovic, S
    Apostolski, S
    Romac, S
    PSYCHIATRIC GENETICS, 2001, 11 (04) : 201 - 205
  • [6] Molecular genetic study of CAG trinucleotide repeat within SCA1 region of hereditary ataxias in the Chinese population
    Zhang, KX
    Zou, Y
    Li, NZ
    Yang, WJ
    Chen, XZ
    JOURNAL OF NEUROCHEMISTRY, 1996, 67 : S35 - S35
  • [7] SCA1 TRANSGENIC MICE - A MODEL FOR NEURODEGENERATION CAUSED BY CAG TRINUCLEOTIDE EXPANSION
    BURRIGHT, EN
    CLARK, HB
    SERVADIO, A
    MATILLA, T
    FEDDERSEN, RM
    YUNIS, WS
    DUVICK, LA
    ZOGHBI, HY
    ORR, HT
    AMERICAN JOURNAL OF HUMAN GENETICS, 1995, 57 (04) : 8 - 8
  • [8] Patterns of CAG repeat interruptions in SCA1 and SCA2 genes in relation to repeat instability
    Sobczak, K
    Krzyzosiak, WJ
    HUMAN MUTATION, 2004, 24 (03) : 236 - 247
  • [9] Trinucleotide repeat expansion of spinocerebellar ataxia (SCA1) found in a Chinese family
    蔡涛
    喻萍
    陈翔
    中华医学杂志(英文版), 1998, (02) : 64 - 66
  • [10] Trinucleotide repeat expansion of spinocerebellar ataxia (SCA1) found in a Chinese family
    蔡涛
    喻萍
    陈翔
    ChineseMedicalJournal, 1998, (02)
12345