Italian Multicenter Study on Accuracy of 18F-FDG PET/CT in Assessing Bone Marrow Involvement in Pediatric Hodgkin Lymphoma

被引：13

作者：

Cistaro, Angelina ^{[1
,2
]}

Cassalia, Laura ^{[1
]}

Ferrara, Cinzia ^{[3
]}

Quartuccio, Natale ^{[4
]}

Evangelista, Laura ^{[5
]}

Bianchi, Maurizio ^{[6
]}

Fagioli, Franca ^{[6
,7
]}

Bisi, Gianni ^{[8
]}

Baldari, Sergio ^{[9
]}

Zanella, Alessandro ^{[10
]}

Pillon, Marta ^{[11
]}

Zucchetta, Pietro ^{[10
]}

Burei, Marta ^{[10
]}

Sala, Alessandra ^{[12
]}

Guerra, Luca ^{[13
]}

Guglielmo, Priscilla ^{[13
]}

Burnelli, Roberta ^{[14
]}

Panareo, Stefano ^{[15
]}

Scalorbi, Federica ^{[16
]}

Rambaldi, Ilaria ^{[15
]}

Piccardo, Arnoldo ^{[17
]}

Garaventa, Alberto ^{[18
]}

Familiari, Demetrio ^{[19
,20
]}

Fornito, Maria Concetta ^{[19
,20
]}

Lopci, Egesta ^{[21
]}

Mascarin, Maurizio ^{[22
]}

Altini, Corinna ^{[23
]}

Ferrari, Cristina ^{[23
]}

Perillo, Teresa ^{[24
]}

Santoro, Nicola ^{[24
]}

Borsatti, Eugenio ^{[25
]}

Rubini, Giuseppe ^{[23
]}

机构：

[1] IRMET SpA, Positron Emiss Tomog Ctr, Affidea, VO Vigliani 89, I-10136 Turin, Italy

[2] Italian Assoc Nucl Med & Mol Imaging, PET Pediat Study Grp, Milan, Italy

[3] Umberto I Hosp, Nucl Med Unit, Syracuse, NY, Italy

[4] Univ Manchester, Wolfson Mol Imaging Ctr, Manchester, England

[5] Ist Ricovero & Cura Carattere Sci, Ist Oncol Veneto, Nucl Med & Mol Imaging Unit, Padua, Italy

[6] Regina Margherita Childrens Hosp, Pediat Oncohematol & Stem Cell Transplant Div, City Hlth & Sci, Turin, Italy

[7] Italian Assoc Pediat Oncol & Hematol, Turin, Italy

[8] Azienda Osped Univ, Div Nucl Med, Citta Salute & Sci, Turin, Italy

[9] Univ Messina, Dept Biomed Sci & Morphol & Funct Images, Nucl Med Unit, Messina, Italy

[10] Univ Hosp, Dept Med, Nucl Med Serv, Padua, Italy

[11] Univ Hosp Padua, Dept Child & Woman Hlth, Div Hematol Oncol, Padua, Italy

[12] San Gerardo Hosp, MBBM Fdn, Maria Letizia Verga Ctr, Monza, Italy

[13] San Gerardo Hosp, Nucl Med Unit, Monza, Italy

[14] Azienda Osped Univ, Osped SantAnna, Oncoematol Pediat, Ferrara, Italy

[15] S Anna Univ Hosp, Dept Diagnost Imaging, Unit Nucl Med, Ferrara, Italy

[16] Univ Bologna, Nucl Med Unit, Bologna, Italy

[17] EO Galliera Hosp, Dept Diagnost Imaging, Nucl Med Unit, Genoa, Italy

[18] Pediat Ist G Gaslini, Dipartimento Ematol & Oncol, Genoa, Italy

[19] ARNAS Garibaldi Nesima, Nucl Med Dept, Catania, Italy

[20] ARNAS Garibaldi Nesima, PET CT Ctr, Catania, Italy

[21] Humanitas Clin & Res Hosp, Nucl Med Dept, Milan, Italy

[22] Ist Ricovero & Cura Carattere Sci, Ctr Riferimento Oncol Aviano, S S Radioterapia Pediat & Area Giovani, Pordenone, Italy

[23] Nucl Med Unit, Pordenone, Italy

[24] Univ Bari, Dept Pediat, Pediat Hematol Oncol Div, Bari, Italy

[25] Natl Canc Inst, Ist Ricovero & Cura Carattere Sci, Nucl Med Unit, Aviano, Italy

来源：

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | 2018年 / 18卷 / 06期

关键词：

BMI; Bone marrow biopsy; Computed tomography; Newly diagnosed pediatric HL; Positron emission tomography; POSITRON-EMISSION-TOMOGRAPHY; FDG-PET; RESPONSE ASSESSMENT; INITIAL EVALUATION; FOLLOW-UP; CHILDREN; DISEASE; BIOPSY; ADOLESCENTS; CHILDHOOD;

D O I：

10.1016/j.clml.2018.04.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The present study investigated the utility of fluorine-18 (F-18) fluoro-2-deoxy-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT) in assessing bone marrow involvement (BMI) compared with bone marrow biopsy (BMB) in newly diagnosed pediatric Hodgkin lymphoma (HL). F-18-FDG PET/CT shows high diagnostic performance in evaluating BMI in pediatric HL. BMB should be ideally reserved for patients with doubtful F-18-FDG PET/CT BMI findings. Introduction: The present study investigated the utility of fluorine-18 (F-18) fluoro-2-deoxy-D-glucose (F-18-FDG) positron emission tomography/computed tomography (PET/CT) in assessing bone marrow involvement (BMI) compared with bone marrow biopsy (BMB) in newly diagnosed pediatric Hodgkin lymphoma (HL). Patients and Methods: A total of 224 pediatric patients with HL underwent F-18-FDG PET/CT at staging. BMB or follow-up imaging was used as the standard of reference for the evaluation of BMI. Results: F-18-FDG PET/CT was negative for BMI in 193 cases. Of the 193 patients, the findings for 16 were originally reported as doubtful and later interpreted as negative for BMI, with negative findings on follow-up imaging and BMB. At BMB, 1 of the 16 patients (6.25%) had BMI. Of the 193 patients, 192 (99.48%) had negative BMB findings. Thus, the F-18-FDG PET/CT findings were truly negative for 192 patients and falsely negative for 1 patient for BMI. Conclusion: F-18-FDG PET/CT showed high diagnostic performance in the evaluation of BMI in pediatric HL. Thus, BMB should be ideally reserved for patients presenting with doubtful F-18-FDG PET/CT findings for BMI.

引用

页码：E267 / E273

页数：7

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