Zonal heterogeneity of peroxisome proliferation in rat liver

被引：19

作者：

Fahimi, HD ^{[1
]}

Beier, K ^{[1
]}

Lindauer, M ^{[1
]}

Schad, A ^{[1
]}

Zhan, J ^{[1
]}

Pill, J ^{[1
]}

Rebel, W ^{[1
]}

Volkl, A ^{[1
]}

Baumgart, E ^{[1
]}

机构：

[1] BOEHRINGER MANNHEIM GMBH, DEPT MED RES, DIABET SECT, D-6800 MANNHEIM, GERMANY

来源：

PEROXISOMES: BIOLOGY AND ROLE IN TOXICOLOGY AND DISEASE | 1996年 / 804卷

关键词：

D O I：

10.1111/j.1749-6632.1996.tb18627.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this review the zonal heterogeneity of distribution of peroxisomes and some of their enzymes in the livers of normal rats and in animals treated with hypolipidemic drugs is presented. After a review of the literature we show our own experimental data, in which morphometry and quantitative immunoelectron microscopy have been used. In addition, novel results obtained by nonradioactive in situ hybridization and by Northern blotting applied to isolated periportal and pericentral hepatocytes are presented. All data show clearly a zonal heterogeneity in the induction of lipid beta-oxidation enzymes and their mRNAs in rat liver with a much stronger response in pericentral (zone 3) than in periportal (zone 1) region of the acinus. Our observations suggest that the differential response of hepatocytes to peroxisome proliferating drugs could be related to the state of differentiation of hepatocytes in the liver acinus.

引用

页码：341 / 361

页数：21

共 55 条

[1]

ANGERMULLER S, 1988, HISTOCHEMISTRY, V88, P277

[2]

ARBER N, 1988, LIVER, V8, P80

[3] INDUCTION OF CYTOCHROME-P450 AND PEROXISOMAL ENZYMES BY CLOFIBRIC ACID INVIVO AND INVITRO [J].

BARS, RG ;

BELL, DR ;

ELCOMBE, CR .

BIOCHEMICAL PHARMACOLOGY, 1993, 45 (10) :2045-2053

[4]

BASS NM, 1989, RBC-CELL BIOL REV, V19, P61

[5]

BAUMGART E, 1987, LAB INVEST, V56, P554

[6] SUPPRESSION OF PEROXISOMAL LIPID BETA-OXIDATION ENZYMES BY TNF-ALPHA [J].

BEIER, K ;

VOLKL, A ;

FAHIMI, HD .

FEBS LETTERS, 1992, 310 (03) :273-276

[7] APPLICATION OF AUTOMATIC IMAGE-ANALYSIS FOR QUANTITATIVE MORPHOLOGICAL-STUDIES OF PEROXISOMES IN RAT-LIVER IN CONJUNCTION WITH CYTOCHEMICAL STAINING WITH 3-3'-DIAMINOBENZIDINE AND IMMUNOCYTOCHEMISTRY [J].

BEIER, K ;

FAHIMI, HD .

MICROSCOPY RESEARCH AND TECHNIQUE, 1992, 21 (04) :271-282

[8] APPLICATION OF AUTOMATIC IMAGE-ANALYSIS FOR MORPHOMETRIC STUDIES OF PEROXISOMES STAINED CYTOCHEMICALLY FOR CATALASE .2. LIGHT-MICROSCOPIC APPLICATION [J].

BEIER, K ;

FAHIMI, HD .

CELL AND TISSUE RESEARCH, 1987, 247 (01) :179-185

[9]

BEIER K, 1988, EUR J CELL BIOL, V46, P383

[10] THE IMPACT OF AGING ON ENZYME PROTEINS OF RAT-LIVER PEROXISOMES - QUANTITATIVE-ANALYSIS BY IMMUNOBLOTTING AND IMMUNOELECTRON MICROSCOPY [J].

BEIER, K ;

VOLKL, A ;

FAHIMI, HD .

VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY, 1993, 63 (03) :139-146

← 1 2 3 4 5 6 →