Technical and regulatory hurdles for DNA vaccines

被引：93

作者：

Donnelly, J ^{[1
]}

Berry, K ^{[1
]}

Ulmer, JB ^{[1
]}

机构：

[1] Chiron Corp, Emeryville, CA 94608 USA

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2003年 / 33卷 / 5-6期

关键词：

adjuvant; DNA delivery; safety; toxicity; vector;

D O I：

10.1016/S0020-7519(03)00056-0

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

DNA vaccines have been widely used in laboratory animals and non-human primates over the last decade to induce antibody and cellular immune responses. This approach has shown some promise, in models of infectious diseases of both bacterial and viral origin as well as in tumour models. Clinical trials have shown that DNA vaccines appear safe and well tolerated, but need to be made much more potent to be candidates for preventive immunisation of humans. This review describes recent work to improve the delivery of plasmid DNA vaccines and also to increase the immunogenicity of antigens expressed from the DNA vaccine plasmids, including various formulations and molecular adjuvants. Because DNA vaccines are relatively new and represent a novel vaccine technology, certain safety issues, such as the potential for induction of autoimmune disease and integration into the host genome, must be examined carefully. If potency can be improved and safety established, plasmid DNA vaccines offer advantages in speed, simplicity, and breadth of immune response that may be useful for the immunisation of humans against infectious diseases and cancers. (C) 2003 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.

引用

页码：457 / 467

页数：11

共 126 条

[1] Stability of peptide condensed plasmid DNA formulations [J].

Adami, RC ;

Collard, WT ;

Gupta, SA ;

Kwok, KY ;

Bonadio, J ;

Rice, KG .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1998, 87 (06) :678-683

[2]

Agadjanyan MG, 1999, J IMMUNOL, V162, P3417

[3] Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine [J].

Amara, RR ;

Villinger, F ;

Altman, JD ;

Lydy, SL ;

O'Neil, SP ;

Staprans, SI ;

Montefiori, DC ;

Xu, Y ;

Herndon, JG ;

Wyatt, LS ;

Candido, MA ;

Kozyr, NL ;

Earl, PL ;

Smith, JM ;

Ma, HL ;

Grimm, BD ;

Hulsey, ML ;

Miller, J ;

McClure, HM ;

McNicholl, JM ;

Moss, B ;

Robinson, HL .

SCIENCE, 2001, 292 (5514) :69-74

[4] Electric pulses increase the immunogenicity of an influenza DNA vaccine injected intramuscularly in the mouse [J].

Bachy, M ;

Boudet, F ;

Bureau, M ;

Girerd-Chambaz, Y ;

Wils, P ;

Scherman, D ;

Meric, C .

VACCINE, 2001, 19 (13-14) :1688-1693

[5]

Barber B H, 1997, Semin Immunol, V9, P293, DOI 10.1006/smim.1997.0085

[6]

Barnes AGC, 2000, CURR OPIN MOL THER, V2, P87

[7] The ability of an oligomeric human immunodeficiency virus type 1 (HIV-1) envelope antigen to elicit neutralizing antibodies against primary HIV-1 isolates is improved following partial deletion of the second hypervariable region [J].

Barnet, SW ;

Lu, S ;

Srivastava, I ;

Cherpelis, S ;

Gettie, A ;

Blanchard, J ;

Wang, S ;

Mboudjeka, I ;

Leung, L ;

Lian, Y ;

Fong, A ;

Buckner, C ;

Ly, A ;

Hilt, S ;

Ulmer, J ;

Wild, CT ;

Mascola, JR ;

Stamatatos, L .

JOURNAL OF VIROLOGY, 2001, 75 (12) :5526-5540

[8] Augmentation of immune responses to HIV-1 and simian immunodeficiency virus DNA vaccines by IL-2/Ig plasmid administration in rhesus monkeys [J].

Barouch, DH ;

Craiu, A ;

Kuroda, MJ ;

Schmitz, JE ;

Zheng, XX ;

Santra, S ;

Frost, JD ;

Krivulka, GR ;

Lifton, MA ;

Crabbs, CL ;

Heidecker, G ;

Perry, HC ;

Davies, ME ;

Xie, H ;

Nickerson, CE ;

Steenbeke, TD ;

Lord, CI ;

Montefiori, DC ;

Strom, TB ;

Shiver, JW ;

Lewis, MG ;

Letvin, NL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (08) :4192-4197

[9] Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination [J].

Barouch, DH ;

Santra, S ;

Schmitz, JE ;

Kuroda, MJ ;

Fu, TM ;

Wagner, W ;

Bilska, M ;

Craiu, A ;

Zheng, XX ;

Krivulka, GR ;

Beaudry, K ;

Lifton, MA ;

Nickerson, CE ;

Trigona, WL ;

Punt, K ;

Freed, DC ;

Guan, LM ;

Dubey, S ;

Casimiro, D ;

Simon, A ;

Davies, ME ;

Chastain, M ;

Strom, TB ;

Gelman, RS ;

Montefiori, DC ;

Lewis, MG ;

Emini, EA ;

Shiver, JW ;

Letvin, NL .

SCIENCE, 2000, 290 (5491) :486-492

[10] Elicitation of high-frequency cytotoxic T-lymphocyte responses against both dominant and subdominant simian-human immunodeficiency virus epitopes by DNA vaccination of rhesus monkeys [J].

Barouch, DH ;

Craiu, A ;

Santra, S ;

Egan, MA ;

Schmitz, JE ;

Kuroda, MJ ;

Fu, TM ;

Nam, JH ;

Wyatt, LS ;

Lifton, MA ;

Krivulka, GR ;

Nickerson, CE ;

Lord, CI ;

Moss, B ;

Lewis, MG ;

Hirsch, VM ;

Shiver, JW ;

Letvin, NL .

JOURNAL OF VIROLOGY, 2001, 75 (05) :2462-2467

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