Failure to Replicate Genetic Associations with Antidepressant Treatment Response in Duloxetine-Treated Patients

被引:64
作者
Perlis, Roy H. [2 ]
Fijal, Bonnie [1 ]
Dharia, Sweta [3 ]
Heinloth, Alexandra N. [3 ]
Houston, John P. [1 ]
机构
[1] Lilly USA LLC, Indianapolis, IN 46285 USA
[2] Massachusetts Gen Hosp, Dept Psychiat, Psychiat Pharmacogenom Lab, Boston, MA 02114 USA
[3] UnitedHlth Grp, Statprobe, Ann Arbor, MI USA
关键词
ABCB1; GRIK4; OPRM1; phosphodiesterases; SLC6A4; SNP; MAJOR DEPRESSIVE DISORDER; SEROTONIN TRANSPORTER; POLYMORPHISMS; CITALOPRAM;
D O I
10.1016/j.biopsych.2009.12.010
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Recent studies have identified associations of polymorphisms in several target genes with antidepressant treatment response of serotonin reuptake inhibitors and a tricyclic antidepressant. We sought to replicate these associations in a study of a serotonin-norepinephrine reuptake inhibitor. Methods: In 250 outpatients with nonpsychotic major depressive disorder, response to treatment with once-daily duloxetine (60 mg/day) over 6 weeks was examined for associations with polymorphisms in eight candidate genes previously associated with antidepressant response using mixed-effect model repeated-measures analysis. Treatment response was quantified on the basis of changes from baseline using 17-item Hamilton Depression Rating Scale total scores. Results: Polymorphisms in PDE1A, PDE1C, PDE6A PDE11A, ABCB1, GRIK4, SLC6A4, and OPRM1 genes showed no statistically significant associations (uncorrected, two-tailed p > .05) with duloxetine treatment response. Conclusions: Previously, described associations between polymorphisms in candidate genes and antidepressant treatment response were not replicated in this study. This result may suggest that previous associations are specific to serotonin reuptake inhibitors.
引用
收藏
页码:1110 / 1113
页数:4
相关论文
共 19 条
[1]   5-HTTLPR polymorphism of the serotonin transporter gene predicts non-remission in major depression patients treated with citalopram in a 12-weeks follow up study [J].
Arias, B ;
Catalán, R ;
Gastó, C ;
Gutiérrez, B ;
Fañanás, L .
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2003, 23 (06) :563-567
[2]   Association study of paroxetine therapeutic response with SERT gene polymorphisms in patients with major depressive disorder [J].
Bozina, Nada ;
Peles, Alma Mihaljevic ;
Sagud, Marina ;
Bilusic, Hrvoje ;
Jakovljevic, Miro .
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 2008, 9 (03) :190-197
[3]   The serotonin transporter polymorphism, 5HTTLPR, is associated with a faster response time to sertraline in an elderly population with major depressive disorder [J].
Durham, LK ;
Webb, SM ;
Milos, PM ;
Clary, CM ;
Seymour, AB .
PSYCHOPHARMACOLOGY, 2004, 174 (04) :525-529
[4]   Familial concordance of fluvoxamine response as a tool for differentiating mood disorder pedigrees [J].
Franchini, L ;
Serretti, A ;
Gasperini, M ;
Smeraldi, E .
JOURNAL OF PSYCHIATRIC RESEARCH, 1998, 32 (05) :255-259
[5]  
GARRIOCK HA, 2008, 7 ANN PHARM PSYCH M
[6]  
Jurinke Christian, 2002, Methods Mol Biol, V187, P179
[7]   Sequence analysis of the serotonin transporter and associations with antidepressant response [J].
Kraft, JB ;
Slager, SL ;
McGrath, PJ ;
Hamilton, SP .
BIOLOGICAL PSYCHIATRY, 2005, 58 (05) :374-381
[8]   Curses-winner's and otherwise-in genetic epidemiology [J].
Kraft, Peter .
EPIDEMIOLOGY, 2008, 19 (05) :649-651
[9]   Pharmacogenetics of the serotonin transporter [J].
Lesch, KP ;
Gutknecht, L .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2005, 29 (06) :1062-1073
[10]   SLC6A4 Variation and Citalopram Response [J].
Mrazek, D. A. ;
Rush, A. J. ;
Blernacka, J. M. ;
O'Kane, D. J. ;
Cunningham, J. M. ;
Wieben, E. D. ;
Schaid, D. J. ;
Drews, M. S. ;
Courson, V. L. ;
Snyder, K. A. ;
Black, J. L., III ;
Weinshilboum, R. M. .
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2009, 150B (03) :341-351