Follicular T helper cells: hotspots for HIV-1 persistence

被引：10
作者：
Paiardini, Mirko [1 ,2 ]
Lichterfeld, Mathias [3 ,4 ,5 ]
机构：
[1] Emory Univ, Sch Med, Dept Pathol, Atlanta, GA 30322 USA
[2] Yerkes Natl Primate Res Ctr, Atlanta, GA USA
[3] Harvard Med Sch, Brigham & Womens Hosp, Div Infect Dis, Boston, MA 02115 USA
[4] MIT, Massachusetts Gen Hosp, Ragon Inst, 77 Massachusetts Ave, Cambridge, MA 02139 USA
[5] Harvard Univ, Cambridge, MA 02138 USA
来源：
NATURE MEDICINE | 2016年 / 22卷 / 07期
关键词：
REPLICATION; RESERVOIR;
D O I：
10.1038/nm.4138
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Reservoirs of virally infected cells that are resistant to standard antiretroviral therapy make HIV-1 infection an incurable disease. A new study shows that follicular T helper cells in lymph node germinal centers are prime niches for HIV-1 persistence during antiviral therapy.
引用
收藏
页码：711 / 712
页数：2
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