An Overview of the Role of Long Non-Coding RNAs in Human Choriocarcinoma

被引：10

作者：

Di Fiore, Riccardo ^{[1
,2
]}

Suleiman, Sherif ^{[1
]}

Felix, Ana ^{[3
]}

O'Toole, Sharon A. ^{[4
,5
]}

O'Leary, John J. ^{[5
]}

Ward, Mark P. ^{[5
]}

Beirne, James ^{[6
]}

Sabol, Maja ^{[7
]}

Ozretic, Petar ^{[7
]}

Yordanov, Angel ^{[8
]}

Vasileva-Slaveva, Mariela ^{[9
]}

Kostov, Stoyan ^{[10
]}

Nikolova, Margarita ^{[11
]}

Said-Huntingford, Ian ^{[12
]}

Ayers, Duncan ^{[13
,14
]}

Ellul, Bridget ^{[13
]}

Pentimalli, Francesca ^{[15
]}

Giordano, Antonio ^{[2
,16
]}

Calleja-Agius, Jean ^{[1
]}

机构：

[1] Univ Malta, Fac Med & Surg, Dept Anat, MSD-2080 Msida, Malta

[2] Temple Univ, Coll Sci & Technol, Ctr Biotechnol, Sbarro Inst Canc Res & Mol Med, Philadelphia, PA 19122 USA

[3] Univ Nova Lisboa, NOVA Med Sch, Inst Portugues Oncol Lisboa, Dept Pathol,Campo Martires Patria, P-1169056 Lisbon, Portugal

[4] Trinity Coll Dublin, Trinity St Jamess Canc Inst, Dept Obstet & Gynaecol, Dublin 8, Ireland

[5] Trinity Coll Dublin, Trinity St Jamess Canc Inst, Dept Histopathol, Dublin 8, Ireland

[6] St James Hosp, Trinity St Jamess Canc Inst, Dept Gynaecol Oncol, Dublin 8, Ireland

[7] Ruder Bogkovic Inst, Div Mol Med, Lab Hereditary Canc, Zagreb 10000, Croatia

[8] Med Univ Pleven, Dept Gynecol Oncol, Pleven 5800, Bulgaria

[9] Alexandrovska Univ Hosp, Dept Surg, Sofia 1431, Bulgaria

[10] Med Univ Varna Prof Dr Paraskev Stoyanov, Dept Gynecol, Varna 9002, Bulgaria

[11] Med Univ Pleven, St Marina Univ Hosp Pleven, Pleven 5800, Bulgaria

[12] Mater Dei Hosp, Dept Histopathol, MSD-2090 Msida, Malta

[13] Univ Malta, Ctr Mol Med & Biobanking, MSD-2080 Msida, Malta

[14] Univ Manchester, Fac Biol Med & Human Sci, Manchester M1 7DN, Lancs, England

[15] Fdn G Pascale, IRCCS, Ist Nazl Tumori, Cell Biol & Biotherapy Unit, I-80131 Naples, Italy

[16] Univ Siena, Dept Med Biotechnol, I-53100 Siena, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 12期

关键词：

choriocarcinoma; rare cancer; long non-coding RNA; oncogenes or tumor suppressor genes; lncRNA-based therapy; GESTATIONAL TROPHOBLASTIC DISEASE; PLACENTA-SPECIFIC; CELL-PROLIFERATION; TUMOR-METASTASIS; HOTAIR PREDICTS; DOWN-REGULATION; POOR-PROGNOSIS; IN-VITRO; CANCER; H19;

D O I：

10.3390/ijms22126506

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Choriocarcinoma (CC), a subtype of trophoblastic disease, is a rare and highly aggressive neoplasm. There are two main CC subtypes: gestational and non-gestational, (so called when it develops as a component of a germ cell tumor or is related to a somatic mutation of a poorly differentiated carcinoma), each with very diverse biological activity. A therapeutic approach is highly effective in patients with early-stage CC. The advanced stage of the disease also has a good prognosis with around 95% of patients cured following chemotherapy. However, advancements in diagnosis and treatment are always needed to improve outcomes for patients with CC. Long non-coding (lnc) RNAs are non-coding transcripts that are longer than 200 nucleotides. LncRNAs can act as oncogenes or tumor suppressor genes. Deregulation of their expression has a key role in tumor development, angiogenesis, differentiation, migration, apoptosis, and proliferation. Furthermore, detection of cancer-associated lncRNAs in body fluids, such as blood, saliva, and urine of cancer patients, is emerging as a novel method for cancer diagnosis. Although there is evidence for the potential role of lncRNAs in a number of cancers of the female genital tract, their role in CC is poorly understood. This review summarizes the current knowledge of lncRNAs in gestational CC and how this may be applied to future therapeutic strategies in the treatment of this rare cancer.

引用

页数：16

共 127 条

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