Self-Healable Antifouling Zwitterionic Hydrogel Based on Synergistic Phototriggered Dynamic Disulfide Metathesis Reaction and Ionic Interaction

A self-healable antifouling hydrogel based on zwitterionic block copolymer was prepared via reversible addition-fragmentation chain transfer polymerization and Diels-Alder "click" chemistry. The hydrogel consists of a core-cross-linked zwitterionic block copolymer having poly(furfuryl methacrylate) as core and poly(dimethyl-[3-(2-methyl-acryloylamino)-propyl]-(3-sulfopropyl)ammonium) (poly(sulfobetaine)) as shell. The core was cross-linked with dithiobismaleimidoethane. The block copolymers were characterized by dynamic light scattering, field emission scanning electron microscopy, high-resolution transmission electron microscopy, atomic force microscopy (AFM), differential scanning calorimetry, water contact angle, and small-angle X-ray scattering analyses. This zwitterionic hydrogel showed self-healing activity via combined effect of phototriggered dynamic disulfide metathesis reaction and zwitterionic interaction, which was monitored by optical microscopy and AFM depth profilometry. The mechanical properties of the hydrogel before and after self-healing were studied using depth sensing nanoindentation method. It was observed that the prepared zwitterionic hydrogel could reduce the formation of biofilm, which was established by studying the bovine serum albumin (model protein) adsorption over the coating. This multifunctional hydrogel can pave a new direction in antifouling self-healable gel coating applications.