Dicarbonyl Stress in the Absence of Hyperglycemia Increases Endothelial Inflammation and Atherogenesis Similar to That Observed in Diabetes
被引:79
作者:
Tikellis, Chris
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Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia
Monash Univ, Cent Clin Sch, Melbourne, Vic 3004, AustraliaBaker IDI Heart & Diabet Inst, Melbourne, Vic, Australia
Tikellis, Chris
[1
,2
]
Pickering, Raelene J.
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Baker IDI Heart & Diabet Inst, Melbourne, Vic, AustraliaBaker IDI Heart & Diabet Inst, Melbourne, Vic, Australia
Pickering, Raelene J.
[1
]
Tsorotes, Despina
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机构:
Baker IDI Heart & Diabet Inst, Melbourne, Vic, AustraliaBaker IDI Heart & Diabet Inst, Melbourne, Vic, Australia
Tsorotes, Despina
[1
]
Huet, Olivier
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Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia
Alfred Hosp, Intens Care Unit, Melbourne, Vic, AustraliaBaker IDI Heart & Diabet Inst, Melbourne, Vic, Australia
Huet, Olivier
[1
,3
]
Cooper, Mark E.
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Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia
Monash Univ, Dept Med, Melbourne, Vic 3004, AustraliaBaker IDI Heart & Diabet Inst, Melbourne, Vic, Australia
Cooper, Mark E.
[1
,4
]
Jandeleit-Dahm, Karin
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Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia
Monash Univ, Dept Med, Melbourne, Vic 3004, AustraliaBaker IDI Heart & Diabet Inst, Melbourne, Vic, Australia
Jandeleit-Dahm, Karin
[1
,4
]
Thomas, Merlin C.
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Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia
Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, AustraliaBaker IDI Heart & Diabet Inst, Melbourne, Vic, Australia
Thomas, Merlin C.
[1
,5
]
机构:
[1] Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia
[2] Monash Univ, Cent Clin Sch, Melbourne, Vic 3004, Australia
[3] Alfred Hosp, Intens Care Unit, Melbourne, Vic, Australia
[4] Monash Univ, Dept Med, Melbourne, Vic 3004, Australia
The deleterious effects of high glucose levels and enhanced metabolic flux on the vasculature are thought to be mediated by the generation of toxic metabolites, including reactive dicarbonyls like methylglyoxal (MG). In this article, we demonstrate that increasing plasma MG to levels observed in diabetic mice either using an exogenous source (1% in drinking water) or generated following inhibition, its primary clearance enzyme, glyoxalase-1 (with 50 mg/kg IP bromobenzyl-glutathione cyclopentyl diester every second day), was able to increase vascular adhesion and augment atherogenesis in euglycemic apolipoprotein E knockout mice to a similar magnitude as that observed in hyperglycemic mice with diabetes. The effects of MG appear partly mediated by activation of the receptor for advanced glycation end products (RAGE), as deletion of RAGE was able to reduce inflammation and atherogenesis associated with MG exposure. However, RAGE deletion did not completely prevent inflammation or vascular damage, possibly because the induction of mitochondrial oxidative stress by dicarbonyls also contributes to inflammation and atherogenesis. Such data would suggest that a synergistic combination of RAGE antagonism and antioxidants may offer the greatest utility for the prevention and management of diabetic vascular complications.
机构:
Queens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North IrelandQueens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland
Berner, A. K.
Brouwers, O.
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h-index: 0
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Univ Maastricht, Dept Internal Med, Maastricht, NetherlandsQueens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland
Brouwers, O.
Pringle, R.
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h-index: 0
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Queens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North IrelandQueens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland
Pringle, R.
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Klaassen, I.
Colhoun, L.
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Queens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North IrelandQueens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland
Colhoun, L.
McVicar, C.
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h-index: 0
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Queens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North IrelandQueens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland
McVicar, C.
Brockbank, S.
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h-index: 0
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Queens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North IrelandQueens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland
Brockbank, S.
Curry, J. W.
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Queens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North IrelandQueens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland
Curry, J. W.
Miyata, T.
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机构:
Tohoku Univ, Grad Sch Med, United Ctr Adv Res & Translat Med ART, Sendai, Miyagi 980, JapanQueens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland
Miyata, T.
Brownlee, M.
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h-index: 0
机构:
Albert Einstein Coll Med, Einstein Diabet Res Ctr, New York, NY USAQueens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland
Brownlee, M.
Schlingemann, R. O.
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机构:
Univ Amsterdam, Acad Med Ctr, Dept Ophthalmol, NL-1105 AZ Amsterdam, Netherlands
Royal Netherlands Acad Arts & Sci KNAW, Netherlands Inst Neurosci, Dept Clin & Mol Ophthalmogenet, Amsterdam, NetherlandsQueens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland
Schlingemann, R. O.
Schalkwijk, C.
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h-index: 0
机构:
Univ Maastricht, Dept Internal Med, Maastricht, NetherlandsQueens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland
Schalkwijk, C.
Stitt, A. W.
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h-index: 0
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Queens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North IrelandQueens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland
机构:
Maastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, NetherlandsMaastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, Netherlands
Brouwers, Olaf
Niessen, Petra M.
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机构:
Maastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, NetherlandsMaastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, Netherlands
Niessen, Petra M.
Ferreira, Isabel
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Maastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, NetherlandsMaastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, Netherlands
Ferreira, Isabel
Miyata, Toshio
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Tohoku Univ, Ctr Translat & Adv Res, Sendai, Miyagi 9808575, JapanMaastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, Netherlands
Miyata, Toshio
Scheffer, Peter G.
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机构:
Vrije Univ Amsterdam, Med Ctr, Dept Clin Chem, NL-1007 MB Amsterdam, NetherlandsMaastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, Netherlands
Scheffer, Peter G.
Teerlink, Tom
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Vrije Univ Amsterdam, Med Ctr, Dept Clin Chem, NL-1007 MB Amsterdam, NetherlandsMaastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, Netherlands
Teerlink, Tom
Schrauwen, Patrick
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Maastricht Univ, Med Ctr, Dept Human Biol, NL-6200 MD Maastricht, NetherlandsMaastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, Netherlands
Schrauwen, Patrick
Brownlee, Michael
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h-index: 0
机构:
Albert Einstein Coll Med, Int Ctr Diabet Complicat Res, Bronx, NY 10461 USAMaastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, Netherlands
Brownlee, Michael
Stehouwer, Coen D.
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h-index: 0
机构:
Maastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, NetherlandsMaastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, Netherlands
Stehouwer, Coen D.
Schalkwijk, Casper G.
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h-index: 0
机构:
Maastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, NetherlandsMaastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, Netherlands
机构:
Queens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North IrelandQueens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland
Berner, A. K.
Brouwers, O.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Maastricht, Dept Internal Med, Maastricht, NetherlandsQueens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland
Brouwers, O.
Pringle, R.
论文数: 0引用数: 0
h-index: 0
机构:
Queens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North IrelandQueens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland
Pringle, R.
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Klaassen, I.
Colhoun, L.
论文数: 0引用数: 0
h-index: 0
机构:
Queens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North IrelandQueens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland
Colhoun, L.
McVicar, C.
论文数: 0引用数: 0
h-index: 0
机构:
Queens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North IrelandQueens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland
McVicar, C.
Brockbank, S.
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h-index: 0
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Queens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North IrelandQueens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland
Brockbank, S.
Curry, J. W.
论文数: 0引用数: 0
h-index: 0
机构:
Queens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North IrelandQueens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland
Curry, J. W.
Miyata, T.
论文数: 0引用数: 0
h-index: 0
机构:
Tohoku Univ, Grad Sch Med, United Ctr Adv Res & Translat Med ART, Sendai, Miyagi 980, JapanQueens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland
Miyata, T.
Brownlee, M.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Einstein Diabet Res Ctr, New York, NY USAQueens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland
Brownlee, M.
Schlingemann, R. O.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Amsterdam, Acad Med Ctr, Dept Ophthalmol, NL-1105 AZ Amsterdam, Netherlands
Royal Netherlands Acad Arts & Sci KNAW, Netherlands Inst Neurosci, Dept Clin & Mol Ophthalmogenet, Amsterdam, NetherlandsQueens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland
Schlingemann, R. O.
Schalkwijk, C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Maastricht, Dept Internal Med, Maastricht, NetherlandsQueens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland
Schalkwijk, C.
Stitt, A. W.
论文数: 0引用数: 0
h-index: 0
机构:
Queens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North IrelandQueens Univ Belfast, Royal Victoria Hosp, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland
机构:
Maastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, NetherlandsMaastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, Netherlands
Brouwers, Olaf
Niessen, Petra M.
论文数: 0引用数: 0
h-index: 0
机构:
Maastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, NetherlandsMaastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, Netherlands
Niessen, Petra M.
Ferreira, Isabel
论文数: 0引用数: 0
h-index: 0
机构:
Maastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, NetherlandsMaastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, Netherlands
Ferreira, Isabel
Miyata, Toshio
论文数: 0引用数: 0
h-index: 0
机构:
Tohoku Univ, Ctr Translat & Adv Res, Sendai, Miyagi 9808575, JapanMaastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, Netherlands
Miyata, Toshio
Scheffer, Peter G.
论文数: 0引用数: 0
h-index: 0
机构:
Vrije Univ Amsterdam, Med Ctr, Dept Clin Chem, NL-1007 MB Amsterdam, NetherlandsMaastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, Netherlands
Scheffer, Peter G.
Teerlink, Tom
论文数: 0引用数: 0
h-index: 0
机构:
Vrije Univ Amsterdam, Med Ctr, Dept Clin Chem, NL-1007 MB Amsterdam, NetherlandsMaastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, Netherlands
Teerlink, Tom
Schrauwen, Patrick
论文数: 0引用数: 0
h-index: 0
机构:
Maastricht Univ, Med Ctr, Dept Human Biol, NL-6200 MD Maastricht, NetherlandsMaastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, Netherlands
Schrauwen, Patrick
Brownlee, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Int Ctr Diabet Complicat Res, Bronx, NY 10461 USAMaastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, Netherlands
Brownlee, Michael
Stehouwer, Coen D.
论文数: 0引用数: 0
h-index: 0
机构:
Maastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, NetherlandsMaastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, Netherlands
Stehouwer, Coen D.
Schalkwijk, Casper G.
论文数: 0引用数: 0
h-index: 0
机构:
Maastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, NetherlandsMaastricht Univ, Med Ctr, Dept Internal Med, Div Gen Internal Med,Lab Metab & Vasc Med, NL-6202 AZ Maastricht, Netherlands