p53 Throws CRISPR a Curve

被引：6

作者：

Carroll, Dana ^{[1
]}

机构：

[1] Univ Utah, Sch Med, Dept Biochem, Salt Lake City, UT 84112 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2018年 / 39卷 / 09期

关键词：

DNA CLEAVAGE; GENOMIC DNA; BASE;

D O I：

10.1016/j.tips.2018.06.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The efficacy of the powerful CRISPR-Cas9 genome-editing platform depends on DNA repair activities in the cells being targeted. Two new papers show that the low efficiency of targeting in some primary human cell lines is the result of p53-dependent cell arrest in response to the Cas9-induced break. This limitation must be overcome for some anticipated therapies.

引用

页码：783 / 784

页数：2

共 8 条

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