Genetics of diabetic nephropathy

被引：23
作者：
Carpena, Mariana P. [1 ]
Rados, Dimitris V.
Sortica, Denise A. [1 ]
de Souza, Bianca M. [1 ]
Reis, Andre Fernandes [3 ]
Canani, Luis Henrique [1 ,2 ]
Crispim, Daisy [1 ,2 ]
机构：
[1] Hosp Clin Porto Alegre, Serv Endocrinol, Porto Alegre, RS, Brazil
[2] Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil
[3] Univ Fed Sao Paulo, Sao Paulo, Brazil
来源：
ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA | 2010年 / 54卷 / 03期
关键词：
Nephropathy; diabetes mellitus; genetics; genetic predisposition; GLOMERULAR-FILTRATION-RATE; URINARY ALBUMIN EXCRETION; CHRONIC KIDNEY-DISEASE; WIDE LINKAGE SCAN; SUSCEPTIBILITY GENES; INSULIN-RESISTANCE; RENAL-DISEASE; INSERTION/DELETION POLYMORPHISM; SEGREGATION ANALYSIS; DECREASED RISK;
D O I：
10.1590/S0004-27302010000300002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The increasing prevalence of diabetes mellitus has led to a growing number of chronic complications including diabetic nephropathy (DN). In addition to its high prevalence, DN is associated with high morbidity and mortality especially due to cardiovascular diseases. It is well established that genetic factors play a role in the pathogenesis of DN and genetically susceptible individuals can develop it after being exposed to environmental factors. DN is probably a complex, polygenic disease. Two main strategies have been used to identify genes associated to DN: analysis of candidate genes, and more recently genome-wide scan. Great efforts have been made to identify these main genes, but results are still inconsistent with different genes associated to a small effect in specific populations. The identification of the main genes would allow the detection of those individuals at high risk for DN and better understanding of its pathophysiology as well. Arq Bras Endocrinol Metab, 2010;54(3):253-61
引用
收藏
页码：253 / 261
页数：9
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