Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies

被引：121

作者：

Minamisawa, S

Oshikawa, J

Takeshima, H

Hoshijima, M

Wang, YB

Chien, KR

Ishikawa, Y

Matsuoka, R

机构：

[1] Yokohama City Univ, Sch Med, Dept Physiol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

[2] Tohoku Univ, Grad Sch Med, Dept Med Chem, Sendai, Miyagi 980, Japan

[3] Univ Calif San Diego, Inst Mol Med, San Diego, CA 92103 USA

[4] Univ Calif Los Angeles, Dept Anesthesiol, David Geffen Sch Med, Los Angeles, CA 90024 USA

[5] Univ Calif Los Angeles, Dept Med, David Geffen Sch Med, Los Angeles, CA 90024 USA

[6] Univ Med & Dent New Jersey, Dept Med Cardiol, Inst Cardiovasc Res, New Jersey Med Sch, Newark, NJ 07103 USA

[7] Univ Med & Dent New Jersey, Dept Cell Biol & Mol Med, Inst Cardiovasc Res, New Jersey Med Sch, Newark, NJ 07103 USA

[8] Tokyo Womens Med Univ, Dept Pediat Cardiol, Shinjuku Ku, Tokyo 1628666, Japan

[9] Tokyo Womens Med Univ, Div Genom Med, Inst Adv Biomed Engn & Sci, Grad Sch Med, Tokyo 1628666, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 325卷 / 03期

关键词：

excitation-contraction; calcium; T-tubules; caveolae; cardiomyopathy; junctional membrane complexes; development; hypertrophy; gene expression;

D O I：

10.1016/j.bbrc.2004.10.107

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Functional coupling between the sarcolemmal membrane and the sarcoplasmic reticulum is based on distinct structures called junctional membrane complexes (JMCs). Recently, junctophilins are found to be responsible for normal formation of JMCs. In the present study, we found that junctophilin type 2 (JP-2), a unique isoform in the heart, was localized in caveolin-rich membranes, and that the expression of JP-2 was up-regulated during normal development and down-regulated in a hypertrophic or a dilated cardiomyopathic mouse model. The expression levels of JP-2 may be associated with the development of T-tubules and impaired Ca2+-induced Ca2+ release in the heart. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：852 / 856

页数：5

共 27 条

[1] MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure [J].