Targeting RAB GTPases to distinct membrane compartments

被引：369

作者：

Pfeffer, S ^{[1
]}

Aivazian, D ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Biochem, Stanford, CA 94305 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm1500

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Rab GTPases are key to membrane-trafficking events in eukaryotic cells, and human cells contain more than 60 Rab proteins that are localized to distinct compartments. The recent determination of the structure of a monoprenylated Rab GTPase bound to GDP-dissociation inhibitor provides new molecular details that are relevant to models of Rab delivery. The further discovery of an integral membrane protein that can dissociate prenylated Rab proteins from GDP-dissociation inhibitor gives new insights into the mechanisms of Rab localization.

引用

页码：886 / 896

页数：11

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