Targeting RAB GTPases to distinct membrane compartments

被引：364
作者：
Pfeffer, S [1 ]
Aivazian, D [1 ]
机构：
[1] Stanford Univ, Sch Med, Dept Biochem, Stanford, CA 94305 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 11期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrm1500
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Rab GTPases are key to membrane-trafficking events in eukaryotic cells, and human cells contain more than 60 Rab proteins that are localized to distinct compartments. The recent determination of the structure of a monoprenylated Rab GTPase bound to GDP-dissociation inhibitor provides new molecular details that are relevant to models of Rab delivery. The further discovery of an integral membrane protein that can dissociate prenylated Rab proteins from GDP-dissociation inhibitor gives new insights into the mechanisms of Rab localization.
引用
收藏
页码：886 / 896
页数：11
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