Cytotoxicity and immunomodulating characteristics of labdane diterpenes from Marrubium cylleneum and Marrubium velutinum

被引：31
|
作者：
Karioti, Anastasia
Skopeliti, Margarita
Tsitsilonis, Ourania
Heilmann, Joerg
Skaltsa, Helen [1 ]
机构：
[1] Univ Athens, Sch Pharm, Dept Pharmacognosy & Chem Nat Prod, GR-15771 Athens, Greece
[2] Univ Athens, Sch Biol, Dept Anim & Human Physiol, Athens 15784, Greece
[3] Univ Regensburg, Inst Pharm, Dept Pharmaceut Biol, D-93040 Regensburg, Germany
来源：
PHYTOCHEMISTRY | 2007年 / 68卷 / 11期
关键词：
Marrubium cylleneum; Marrubium velutinum; lamiaceae; labdane diterpenes; Nor-diterpenes; cytotoxicity; lymphocyte activation;
D O I：
10.1016/j.phytochem.2007.03.027
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
From the aerial parts of Marrubium cylleneum, one labdane nor-diterpene has been isolated together with two labdane diterpenes, hitherto not known as natural products. The structures of the isolated compounds were established by means of NMR [H-1-H-1-COSY, H-1-C-13-HSQC, HMQC-TOCSY, HMBC, NOESY] and MS spectral analyses. Several diterpenoids from M. cylleneum and M. velutinum were tested for their cytotoxic effect against various cancer cell lines and their immunomodulating potential in human peripheral blood mononuclear cells in standard in vitro assays. Our results show a differential cytotoxicity of some compounds as well as their ability to improve selected lymphocyte functions. (c) 2007 Elsevier Ltd. All rights reserved.
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收藏
页码：1587 / 1594
页数：8
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