Associations between Single Nucleotide Polymorphisms in the Mitochondrial DNA D-Loop Region and Outcome of Gastroenteropancreatic Neuroendocrine Neoplasm

被引：2

作者：

Er, Li-Mian ^{[1
]}

Li, Yong ^{[2
]}

Er, Li ^{[3
]}

Wu, MingLi ^{[1
]}

Zheng, Xiu-li ^{[1
]}

Guo, Zhan-jun ^{[1
]}

Yuan, Hu-Fang ^{[2
]}

机构：

[1] Hebei Med Univ, Dept Endoscopy, Hosp 4, 12 Jian Kang Rd, Shijiazhuang 050011, Hebei, Peoples R China

[2] Hebei Med Univ, Hosp 4, Dept Surg 3, Shijiazhuang, Hebei, Peoples R China

[3] Youhao Hosp Yangzhou, Dept ICU, Yangzhou, Jiangsu, Peoples R China

来源：

ANNALS OF CLINICAL AND LABORATORY SCIENCE | 2018年 / 48卷 / 03期

关键词：

Gastroenteropancreatic neuroendocrine neoplasm; SNPs; D-loop; mtDNA; Survival; NON-HODGKIN-LYMPHOMA; SEQUENCE POLYMORPHISMS; PROGNOSTIC-FACTORS; DISPLACEMENT LOOP; LUNG-CANCER; RISK-FACTOR; MUTATIONS; TUMORS; IDENTIFICATION;

D O I：

暂无

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Accumulation of single-nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) may be associated with cancer risk and disease outcome. We evaluated the predictive value of these SNPs for GEP-NEN outcome. Three SNP sites of nucleotides16257C/A, 150C/T and 151C/Tdel were identified for statistically significant prediction of postoperative survival in GEP-NEN by univariate analysis with log-rank test. In addition, the minor haplotype of nucleotides 16257A in the hypervariable segment 1(HV1) region of the D-loop was identified for their association with lower survival rate of GEP-NEN (relative risk, 3.390; 95% CI, 1.071 similar to 10.729; p=0.038) by multivariate analysis with COX hazards model. The analysis of genetic polymorphisms in the mitochondrial D-loop can help identify patient subgroups with a high risk of GEP-NEN outcome.

引用

页码：333 / 337

页数：5

共 31 条

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