Comparison of 6-Month Outcomes of Survivors of COVID-19 versus Non-COVID-19 Critical Illness

被引：70

作者：

Hodgson, Carol L. ^{[1
,3
,4
]}

Higgins, Alisa M. ^{[1
]}

Bailey, Michael J. ^{[1
]}

Mather, Anne M. ^{[1
]}

Beach, Lisa ^{[5
]}

Bellomo, Rinaldo ^{[1
,6
,8
]}

Bissett, Bernie ^{[9
,10
]}

Boden, Ianthe J. ^{[11
,12
]}

Bradley, Scott ^{[4
]}

Burrell, Aidan ^{[1
,3
]}

Cooper, D. James ^{[1
,3
]}

Fulcher, Bentley J. ^{[1
]}

Haines, Kimberley J. ^{[6
,13
]}

Hodgson, Isabelle T. ^{[1
]}

Hopkins, Jack ^{[1
]}

Jones, Alice Y. M. ^{[14
]}

Lane, Stuart ^{[1
,15
]}

Lawrence, Drew ^{[4
]}

van der Lee, Lisa ^{[16
]}

Liacos, Jennifer ^{[4
]}

Linke, Natalie J. ^{[1
]}

Gomes, Lonni Marques ^{[1
]}

Nickels, Marc ^{[17
]}

Ntoumenopoulos, George ^{[18
]}

Myles, Paul S. ^{[2
]}

Patman, Shane ^{[19
]}

Paton, Michelle ^{[1
,20
]}

Pound, Gemma ^{[1
,21
]}

Rai, Sumeet ^{[22
,23
]}

Rix, Alana ^{[4
]}

Rollinson, Thomas C. ^{[7
,24
]}

Tipping, Claire J. ^{[4
]}

Thomas, Peter ^{[25
]}

Trapani, Tony ^{[1
]}

Udy, Andrew A. ^{[1
,3
]}

Whitehead, Christina ^{[1
,15
]}

Anderson, Shannah ^{[1
]}

Neto, Ary Serpa ^{[1
,6
,8
,26
]}

机构：

[1] Monash Univ, Australian & New Zealand Intens Care Res Ctr, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia

[2] Monash Univ, Dept Anaesthesiol & Perioperat Med, Cent Clin Sch, Melbourne, Vic, Australia

[3] The Alfred, Dept Intens Care & Hyperbar Med, Melbourne, Vic, Australia

[4] The Alfred, Dept Physiotherapy, Melbourne, Vic, Australia

[5] Royal Melbourne Hosp, Dept Physiotherapy Allied Hlth, Melbourne, Vic, Australia

[6] Univ Melbourne, Dept Crit Care, Melbourne, Vic, Australia

[7] Univ Melbourne, Dept Physiotherapy, Melbourne, Vic, Australia

[8] Austin Hosp, Data Analyt Res & Evaluat Dare Ctr, Melbourne, Vic, Australia

[9] Univ Canberra, Discipline Physiotherapy, Canberra, ACT, Australia

[10] Canberra Hosp, Physiotherapy Dept, Canberra, ACT, Australia

[11] Launceston Gen Hosp, Physiotherapy Dept, Launceston, Tas, Australia

[12] Univ Tasmania, Sch Med, Hobart, Tas, Australia

[13] Western Hlth, Physiotherapy Dept, Melbourne, Vic, Australia

[14] Univ Queensland, Sch Hlth & Rehabil Sci, Brisbane, Qld, Australia

[15] Nepean Hosp, Intens Care Med, Kingswood, NSW, Australia

[16] Fiona Stanley Hosp, Perth, WA, Australia

[17] Princess Alexandra Hosp, Physiotherapy Dept, Metro South Hlth, Woolloongabba, Qld, Australia

[18] St Vincents Hosp, Physiotherapy, Sydney, NSW, Australia

[19] Univ Notre Dame Australia, Fac Med Nursing & Midwifery Hlth Sci & Physiother, Perth, WA, Australia

[20] Monash Hlth, Dept Physiotherapy, Melbourne, Vic, Australia

[21] St Vincents Hosp, Physiotherapy Dept, Melbourne, Vic, Australia

[22] Canberra Hlth Serv, Canberra, ACT, Australia

[23] Australia Natl Univ, Med Sch, Canberra, ACT, Australia

[24] Austin Hlth, Div Allied Hlth, Dept Physiotherapy, Melbourne, Vic, Australia

[25] Royal Brisbane & Womens Hosp, Dept Physiotherapy, Brisbane, Qld, Australia

[26] Hosp Israelita Albert Einstein, Dept Crit Care Med, Sao Paulo, Brazil

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2022年 / 205卷 / 10期

关键词：

SARS-CoV-2; long COVID; critical care; recovery; long-term outcomes; INTENSIVE-CARE; DISABILITY; RECOVERY;

D O I：

10.1164/rccm.202110-2335OC

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Rationale: The outcomes of survivors of critical illness due to coronavirus disease (COVID-19) compared with non-COVID-19 are yet to be established. Objectives: We aimed to investigate new disability at 6 months in mechanically ventilated patients admitted to Australian ICUs with COVID-19 compared with non-COVID-19. Methods: We included critically ill patients with COVID-19 and non-COVID-19 from two prospective observational studies. Patients were eligible if they were adult (age >= 8 yr) and received >= 24 hours of mechanical ventilation. In addition, patients with COVID-19 were eligible with a positive laboratory PCR test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Measurements and Main Results: Demographic, intervention, and hospital outcome data were obtained from electronic medical records. Survivors were contacted by telephone for functional outcomes with trained outcome assessors using the World Health Organization Disability Assessment Schedule 2.0. Between March 6, 2020, and April 21, 2021, 120 critically ill patients with COVID-19, and between August 2017 and January 2019, 199 critically ill patients without COVID-19, fulfilled the inclusion criteria. Patients with COVID-19 were older (median [interquartile range], 62 [55-71] vs. 58 [44-69] yr; P= 0.019) with a lower Acute Physiology and Chronic Health Evaluation II score (17 [13-20] vs. 19 [15-23]; P= 0.011). Although duration of ventilation was longer in patients with COVID-19 than in those without COVID-19 (12 [5-19] vs. 4.8 [2.3-8.8] d; P < 0.001), 180-day mortality was similar between the groups (39/120 [32.5%] vs. 70/199 [35.2%]; P = 0.715). The incidence of death or new disability at 180 days was similar (58/93 [62.4%] vs. 99/150 [6610%]; P=0.583). Conclusions: At 6 months, there was no difference in new disability for patients requiring mechanical ventilation for acute respiratory failure due to COVID-19 compared with non-COVID-19.

引用

页码：1159 / 1168

页数：10

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