Thrombolytic strategies for ischemic stroke in the thrombectomy era

被引：43

作者：

Gauberti, Maxime ^{[1
,2
]}

Martinez de Lizarrondo, Sara ^{[1
]}

Vivien, Denis ^{[1
,3
]}

机构：

[1] Normandie Univ, Inst Blood & Brain Caen Normandie, INSERM, UNICAEN,PhIND Physiopathol & Imaging Neurol Disor, Caen, France

[2] CHU Caen Cote Nacre, Dept Neuroradiol, CHU Caen, Caen, France

[3] CHU Caen Cote Nacre, Clin Res Dept, CHU Caen, Caen, France

来源：

JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2021年 / 19卷 / 07期

关键词：

fibrinolysis; ischemia; reperfusion; ischemic stroke; thrombectomy; tissue‐ type plasminogen activator; TISSUE-PLASMINOGEN ACTIVATOR; MECHANICAL THROMBECTOMY; INTRAVENOUS THROMBOLYSIS; INFARCT SIZE; FIBRINOLYSIS INHIBITOR; EARLY RECANALIZATION; VWF BLOCKADE; THROMBOSIS; EFFICACY; TAFI;

D O I：

10.1111/jth.15336

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Twenty-five years ago, intravenous thrombolysis has revolutionized the care of patients with acute ischemic stroke. Since 2015, randomized clinical trials have demonstrated that mechanical thrombectomy improves functional outcome in stroke patients over intravenous thrombolysis alone. More recently, three randomized clinical trials have suggested that mechanical thrombectomy alone is noninferior to a combined strategy with both intravenous thrombolysis and mechanical thrombectomy. In the present review, we will present the last clinical and preclinical studies on the use of thrombolysis in stroke patients in the modern thrombectomy era. At the cost of a potential increased risk of hemorrhagic transformation, thrombolysis may promote arterial recanalization before thrombectomy, improve the rate of successful recanalization after thrombectomy, and restore microcirculation patency downstream of the main thrombus. Besides, new thrombolytic strategies targeting tissue-type plasminogen activator resistant thrombi are being developed, which could strengthen the beneficial effects of thrombolysis without carrying additional pro-hemorrhagic effects. For instance, tenecteplase has shown improved rate of recanalization compared with tissue-type plasminogen activator (alteplase). Beyond fibrinolysis, DNA- and von Willebrand factor-targeted thrombolytic strategies have shown promising results in experimental models of ischemic stroke. New combined strategies, improved thrombolytics, and dedicated clinical trials in selected patients are eagerly awaited to further improve functional outcome in stroke.

引用

页码：1618 / 1628

页数：11

共 87 条

[1] Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging [J].

Albers, G. W. ;

Marks, M. P. ;

Kemp, S. ;

Christensen, S. ;

Tsai, J. P. ;

Ortega-Gutierrez, S. ;

McTaggart, R. A. ;

Torbey, M. T. ;

Kim-Tenser, M. ;

Leslie-Mazwi, T. ;

Sarraj, A. ;

Kasner, S. E. ;

Ansari, S. A. ;

Yeatts, S. D. ;

Hamilton, S. ;

Mlynash, M. ;

Heit, J. J. ;

Zaharchuk, G. ;

Kim, S. ;

Carrozzella, J. ;

Palesch, Y. Y. ;

Demchuk, A. M. ;

Bammer, R. ;

Lavori, P. W. ;

Broderick, J. P. ;

Lansberg, M. G. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (08) :708-718

[2] Thrombus Migration Paradox in Patients With Acute Ischemic Stroke [J].

Alves, Heitor C. ;

Treurniet, Kilian M. ;

Jansen, Ivo G. H. ;

Yoo, Albert J. ;

Dutra, Bruna G. ;

Zhang, Guang ;

Yo, Lonneke ;

van Es, Adriaan C. G. M. ;

Emmer, Bart J. ;

van den Berg, Rene ;

van den Wijngaard, Ido R. ;

Nijeholt, Geert J. Lycklama a ;

Vos, Jan-Albert ;

Roos, Yvo B. W. E. M. ;

Schonewille, Wouter ;

Marquering, Henk A. ;

Majoie, Charles B. L. M. .

STROKE, 2019, 50 (11) :3156-3163

[3] A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke [J].

Berkhemer, O. A. ;

Fransen, P. S. S. ;

Beumer, D. ;

van den Berg, L. A. ;

Lingsma, H. F. ;

Yoo, A. J. ;

Schonewille, W. J. ;

Vos, J. A. ;

Nederkoorn, P. J. ;

Wermer, M. J. H. ;

van Walderveen, M. A. A. ;

Staals, J. ;

Hofmeijer, J. ;

van Oostayen, J. A. ;

Nijeholt, G. J. Lycklama A. ;

Boiten, J. ;

Brouwer, P. A. ;

Emmer, B. J. ;

de Bruijn, S. F. ;

van Dijk, L. C. ;

Kappelle, L. J. ;

Lo, R. H. ;

Van Dijk, E. J. ;

de Vries, J. ;

de Kort, P. L. M. ;

van Rooij, W. J. J. ;

van den Berg, J. S. P. ;

van Hasselt, B. A. A. M. ;

Aerden, L. A. M. ;

Dallinga, R. J. ;

Visser, M. C. ;

Bot, J. C. J. ;

Vroomen, P. C. ;

Eshghi, O. ;

Schreuder, T. H. C. M. L. ;

Heijboer, R. J. J. ;

Keizer, K. ;

Tielbeek, A. V. ;

den Hertog, H. M. ;

Gerrits, D. G. ;

van den Berg-Vos, R. M. ;

Karas, G. B. ;

Steyerberg, E. W. ;

Flach, H. Z. ;

Marquering, H. A. ;

Sprengers, M. E. S. ;

Jenniskens, S. F. M. ;

Beenen, L. F. M. ;

van den Berg, R. ;

Koudstaal, P. J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (01) :11-20

[4] Low Rates of Acute Recanalization With Intravenous Recombinant Tissue Plasminogen Activator in Ischemic Stroke Real-World Experience and a Call for Action [J].

Bhatia, Rohit ;

Hill, Michael D. ;

Shobha, Nandavar ;

Menon, Bijoy ;

Bal, Simerpreet ;

Kochar, Puneet ;

Watson, Tim ;

Goyal, Mayank ;

Demchuk, Andrew M. .

STROKE, 2010, 41 (10) :2254-2258

[5] Recent Advances in Nanomedicine for Ischemic and Hemorrhagic Stroke [J].

Bonnard, Thomas ;

Gauberti, Maxime ;

de Lizarrondo, Sara Martinez ;

Campos, Francisco ;

Vivien, Denis .

STROKE, 2019, 50 (05) :1318-1324

[6] Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke (THRACE): a randomised controlled trial [J].

Bracard, Serge ;

Ducrocq, Xavier ;

Mas, Jean Louis ;

Soudant, Marc ;

Oppenheim, Catherine ;

Moulin, Thieriy ;

Guillemin, Francis .

LANCET NEUROLOGY, 2016, 15 (11) :1138-1147

[7] Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke [J].

Campbell, B. C. V. ;

Mitchell, P. J. ;

Churilov, L. ;

Yassi, N. ;

Kleinig, T. J. ;

Dowling, R. J. ;

Yan, B. ;

Bush, S. J. ;

Dewey, H. M. ;

Thijs, V. ;

Scroop, R. ;

Simpson, M. ;

Brooks, M. ;

Asadi, H. ;

Wu, T. Y. ;

Shah, D. G. ;

Wijeratne, T. ;

Ang, T. ;

Miteff, F. ;

Levi, C. R. ;

Rodrigues, E. ;

Zhao, H. ;

Salvaris, P. ;

Garcia-Esperon, C. ;

Bailey, P. ;

Rice, H. ;

de Villiers, L. ;

Brown, H. ;

Redmond, K. ;

Leggett, D. ;

Fink, J. N. ;

Collecutt, W. ;

Wong, A. A. ;

Muller, C. ;

Coulthard, A. ;

Mitchell, K. ;

Clouston, J. ;

Mahady, K. ;

Field, D. ;

Ma, H. ;

Phan, T. G. ;

Chong, W. ;

Chandra, R. V. ;

Slater, L. -A. ;

Krause, M. ;

Harrington, T. J. ;

Faulder, K. C. ;

Steinfort, B. S. ;

Bladin, C. F. ;

Sharma, G. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (17) :1573-1582

[8]

Campbell BCV, 2020, LANCET, V396, P129, DOI 10.1016/S0140-6736(20)31179-X

[9] Effect of Intravenous Tenecteplase Dose on Cerebral Reperfusion Before Thrombectomy in Patients With Large Vessel Occlusion Ischemic Stroke The EXTEND-IA TNK Part 2 Randomized Clinical Trial [J].

Campbell, Bruce C. V. ;

Mitchell, Peter J. ;

Churilov, Leonid ;

Yassi, Nawaf ;

Kleinig, Timothy J. ;

Dowling, Richard J. ;

Yan, Bernard ;

Bush, Steven J. ;

Thijs, Vincent ;

Scroop, Rebecca ;

Simpson, Marion ;

Brooks, Mark ;

Asadi, Hamed ;

Wu, Teddy Y. ;

Shah, Darshan G. ;

Wijeratne, Tissa ;

Zhao, Henry ;

Alemseged, Fana ;

Ng, Felix ;

Bailey, Peter ;

Rice, Henry ;

de Villiers, Laetitia ;

Dewey, Helen M. ;

Choi, Philip M. C. ;

Brown, Helen ;

Redmond, Kendal ;

Leggett, David ;

Fink, John N. ;

Collecutt, Wayne ;

Kraemer, Thomas ;

Krause, Martin ;

Cordato, Dennis ;

Field, Deborah ;

Ma, Henry ;

O'Brien, Bill ;

Clissold, Benjamin ;

Miteff, Ferdinand ;

Clissold, Anna ;

Cloud, Geoffrey C. ;

Bolitho, Leslie E. ;

Bonavia, Luke ;

Bhattacharya, Arup ;

Wright, Alistair ;

Mamun, Abul ;

O'Rourke, Fintan ;

Worthington, John ;

Wong, Andrew A. ;

Levi, Christopher R. ;

Bladin, Christopher F. ;

Sharma, Gagan .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (13) :1257-1265

[10] Recanalization of Emergent Large Intracranial Vessel Occlusion through Intravenous Thrombolysis: Frequency, Clinical Outcome, and Reperfusion Pattern [J].

Candel, Carmen Serna ;

Aguilar Perez, Marta ;

Hellstern, Victoria ;

AlMatter, Muhammad ;

Baezner, Hansjoerg ;

Henkes, Hans .

CEREBROVASCULAR DISEASES, 2019, 48 (3-6) :115-123

← 1 2 3 4 5 6 7 8 9 →