Terpenoids from the Root Bark of Pterolobium macropterum

被引：13

作者：

Suthiwong, Jittra ^{[1
]}

Pitchuanchom, Siripit ^{[3
,4
]}

Wattanawongdon, Wareepom ^{[2
]}

Hahnvajanawong, Chariya ^{[2
]}

Yenjai, Chavi ^{[1
]}

机构：

[1] Khon Kaen Univ, Fac Sci, Nat Prod Res Unit, Ctr Excellence Innovat Chem,Dept Chem, Khon Kaen 40002, Thailand

[2] Khon Kaen Univ, Fac Med, Dept Microbiol, Liver Fluke & Cholangiocarcinoma Res Ctr, Khon Kaen 40002, Thailand

[3] Lampang Rajabhat Univ, Fac Sci, Lab Nat Prod, Lampang 52100, Thailand

[4] Lampang Rajabhat Univ, Ctr Excellence Innovat Chem, Lampang 52100, Thailand

来源：

JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 11期

关键词：

CAESALPINIA-CRISTA; CHOLANGIOCARCINOMA; CYTOTOXICITY; DITERPENOIDS; CONSTITUENTS;

D O I：

10.1021/np500476h

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new compounds, including pteroloterins A-C (1, 3, and 4), 1 beta-acetoxytaepeenin C (2), and 8aa-hydroxycadinenal (5), and 11 known compounds were isolated from the root bark of Pterolobium macropterum. All compounds were evaluated for cytotoxicity against the cholangiocarcinoma cell lines. Compound 9 showed weak cytotoxicity against the KKU-M139 cell line with an IC50 value of 23.24 +/- 0.18 mu M and showed no activity against normal cells.

引用

页码：2432 / 2437

页数：6

共 14 条

[11] Antioxidant activity and cytotoxicity against cholangiocarcinoma of carbazoles and coumarins from Clausena harmandiana [J].