Terpenoids from the Root Bark of Pterolobium macropterum

被引：13
作者：
Suthiwong, Jittra [1 ]
Pitchuanchom, Siripit [3 ,4 ]
Wattanawongdon, Wareepom [2 ]
Hahnvajanawong, Chariya [2 ]
Yenjai, Chavi [1 ]
机构：
[1] Khon Kaen Univ, Fac Sci, Nat Prod Res Unit, Ctr Excellence Innovat Chem,Dept Chem, Khon Kaen 40002, Thailand
[2] Khon Kaen Univ, Fac Med, Dept Microbiol, Liver Fluke & Cholangiocarcinoma Res Ctr, Khon Kaen 40002, Thailand
[3] Lampang Rajabhat Univ, Fac Sci, Lab Nat Prod, Lampang 52100, Thailand
[4] Lampang Rajabhat Univ, Ctr Excellence Innovat Chem, Lampang 52100, Thailand
来源：
JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 11期
关键词：
CAESALPINIA-CRISTA; CHOLANGIOCARCINOMA; CYTOTOXICITY; DITERPENOIDS; CONSTITUENTS;
D O I：
10.1021/np500476h
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Five new compounds, including pteroloterins A-C (1, 3, and 4), 1 beta-acetoxytaepeenin C (2), and 8aa-hydroxycadinenal (5), and 11 known compounds were isolated from the root bark of Pterolobium macropterum. All compounds were evaluated for cytotoxicity against the cholangiocarcinoma cell lines. Compound 9 showed weak cytotoxicity against the KKU-M139 cell line with an IC50 value of 23.24 +/- 0.18 mu M and showed no activity against normal cells.
引用
收藏
页码：2432 / 2437
页数：6
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