Enantioselective organocatalytic conjugate addition of amines to α,β-unsaturated aldehydes:: one-pot asymmetric synthesis of β-amino acids and 1,3-diamines

被引：97

作者：

Vesely, Jan ^{[1
]}

Ibrahem, Ismail ^{[1
]}

Rios, Ramon ^{[1
]}

Zhao, Gui-Ling ^{[1
]}

Xu, Yongmei ^{[1
]}

Cordova, Armando ^{[1
]}

机构：

[1] Univ Stockholm, Arrhenius Lab, Dept Organ Chem, S-10691 Stockholm, Sweden

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 12期

关键词：

CROSS-MANNICH REACTION; CHIRAL AMMONIA EQUIVALENT; DIELS-ALDER REACTIONS; AZA-MICHAEL REACTION; ALPHA-AMINO; DERIVATIVES; CATALYSIS; 3-COMPONENT; CYCLIZATION; ENANTIOMER;

D O I：

10.1016/j.tetlet.2007.01.093

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Organocatalytic asymmetric amine conjugate additions to alpha, beta-unsaturated aldehydes catalyzed by protected diarylprolinols are presented. The reactions proceed with high enantioselectivity and result in Cbz or Boc protected beta-amino aldehydes, gamma-amino alcohols, beta-amino acids and 1,3-diamines with typically 82-99% ee. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2193 / 2198

页数：6

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