Copeptin as a diagnostic PH marker in acute pulmonary embolism

被引：0

作者：

Baykan, Necmi ^{[1
]}

Yakar, Sule ^{[2
]}

Ozkan, Seda ^{[3
]}

Sen, Ahmet ^{[4
]}

Salt, Omer ^{[5
]}

Durukan, Polat ^{[6
]}

机构：

[1] Nevsehir State Hosp, Dept Emergency Med, Nevsehir, Turkey

[2] Kayseri City Training & Res Hosp, Dept Emergency Med, Kayseri, Turkey

[3] Istanbul Univ, Cerrahpasa Fac Med, Dept Emergency Med, Istanbul, Turkey

[4] Educ & Res Hosp, Dept Biochem, Van, Turkey

[5] Trakya Univ, Dept Emergency Med, Sch Med, Edirne, Turkey

[6] Med Pk Hosp, Dept Emergency Med, Gaziantep, Turkey

来源：

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES | 2022年 / 12卷 / 04期

关键词：

Pulmonary embolism; mortality; pulmonary wedge pressure; right ventricular dysfunction; VASOPRESSIN; PRECURSOR;

D O I：

10.33808/clinexphealthsci.1054109

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objective: The present study aimed to investigate the effectiveness of copeptin levels in detecting increased pulmonary artery pressure and right ventricular dysfunction in patients with acute pulmonary embolism. Methods: A total of 116 patients who presented to the emergency department with chest pain or dyspnea and were diagnosed with acute pulmonary embolism and 30 healthy controls were included in the study. Plasma copeptin levels of patients and healthy control group were measured. Right ventricular functions and pulmonary artery pressures were evaluated in echocardiography of patients diagnosed with acute pulmonary embolism. Results: Copeptin levels were significantly higher in patients with right ventricular dysfunction than in those without right ventricular dysfunction [median 1.06(0.03-7.14) vs. 0.59(0.31-2.50), p= 0.01]. Conclusion: Copeptin can be used as a new biomarker in the diagnosis of acute pulmonary embolism and in predicting right ventricular dysfunction and increased pulmonary artery pressure in patients with acute pulmonary embolism.

引用

页码：1040 / 1045

页数：6

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