Novel intramolecular rearrangement leading to the synthesis of biheterocyclic indole-benzoimidazole derivatives on solid phase

被引：19

作者：

Roy, AD ^{[1
]}

Sharma, S

Grover, RK

Kundu, B

Roy, R

机构：

[1] Cent Drug Res Inst, Div SAIF, Lucknow 226001, Uttar Pradesh, India

[2] Cent Drug Res Inst, Div Med & Proc Chem, Lucknow 226001, Uttar Pradesh, India

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 25期

关键词：

D O I：

10.1021/ol0479794

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel intramolecular SNAr rearrangement observed during the S-alkylation of benzoimidazole-2-thione with alpha-haloacetophenone is reported. The rearrangement led to the formation of a new benzoimidazole-based intermediate, which is further utilized for the generation of a new biheterocyclic indole-benzimidazole derivatives with a two-point diversity.

引用

页码：4763 / 4766

页数：4

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