Targeted therapies in interstitial lung disease secondary to systemic autoimmune rheumatic disease. Current status and future development

被引：10

作者：

Karakontaki, Foteini, V ^{[1
]}

Panselinas, Efstratios S. ^{[2
]}

Polychronopoulos, Vlasios S. ^{[1
]}

Tzioufas, Athanasios G. ^{[3
]}

机构：

[1] Hygeia Hosp, Dept Pulm Med, Athens, Greece

[2] Pulmonologist, Tripoli, Greece

[3] Univ Athens, Sch Med, Dept Pathophysiol, 75 M Asias St,Bldg 16,Room 32, Athens 11527, Greece

来源：

AUTOIMMUNITY REVIEWS | 2021年 / 20卷 / 02期

关键词：

Autoimmune rheumatic diseases; Interstitial lung disease; Rheumatoid arthritis; Sjogren's syndrome; Vasculitis; Myositis; Scleroderma immunosuppressive drugs; Targeted treatment; Anti-fibrotic treatment; CONNECTIVE-TISSUE DISEASE; ANTI-SYNTHETASE SYNDROME; PRIMARY SJOGRENS-SYNDROME; MYCOPHENOLATE-MOFETIL; OPEN-LABEL; RITUXIMAB THERAPY; IMATINIB MESYLATE; ARTHRITIS; SCLEROSIS; EFFICACY;

D O I：

10.1016/j.autrev.2020.102742

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoimmune rheumatic diseases (ARD) are characterized by systemic manifestations and multiple organ involvement, including the lung. Interstitial Lung Disease (ILD) is a cardinal manifestation of lung involvement in patients with ARD and is associated with significant morbidity and mortality. Corticosteroids and immunosuppressive drugs are used as first -line treatment. Targeted therapies, such as biological disease modifying anti-rheumatic drugs (DMARDS) and anti- fibrotic agents are new treatment options. In this review we discuss the role of targeted therapies in patients with ILD secondary to ARD.

引用

页数：7

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