Targeted therapies in interstitial lung disease secondary to systemic autoimmune rheumatic disease. Current status and future development

被引：10
|
作者：
Karakontaki, Foteini, V [1 ]
Panselinas, Efstratios S. [2 ]
Polychronopoulos, Vlasios S. [1 ]
Tzioufas, Athanasios G. [3 ]
机构：
[1] Hygeia Hosp, Dept Pulm Med, Athens, Greece
[2] Pulmonologist, Tripoli, Greece
[3] Univ Athens, Sch Med, Dept Pathophysiol, 75 M Asias St,Bldg 16,Room 32, Athens 11527, Greece
来源：
AUTOIMMUNITY REVIEWS | 2021年 / 20卷 / 02期
关键词：
Autoimmune rheumatic diseases; Interstitial lung disease; Rheumatoid arthritis; Sjogren's syndrome; Vasculitis; Myositis; Scleroderma immunosuppressive drugs; Targeted treatment; Anti-fibrotic treatment; CONNECTIVE-TISSUE DISEASE; ANTI-SYNTHETASE SYNDROME; PRIMARY SJOGRENS-SYNDROME; MYCOPHENOLATE-MOFETIL; OPEN-LABEL; RITUXIMAB THERAPY; IMATINIB MESYLATE; ARTHRITIS; SCLEROSIS; EFFICACY;
D O I：
10.1016/j.autrev.2020.102742
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Autoimmune rheumatic diseases (ARD) are characterized by systemic manifestations and multiple organ involvement, including the lung. Interstitial Lung Disease (ILD) is a cardinal manifestation of lung involvement in patients with ARD and is associated with significant morbidity and mortality. Corticosteroids and immunosuppressive drugs are used as first -line treatment. Targeted therapies, such as biological disease modifying anti-rheumatic drugs (DMARDS) and anti- fibrotic agents are new treatment options. In this review we discuss the role of targeted therapies in patients with ILD secondary to ARD.
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页数：7
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