Synthesis and properties of polyaromatic dendrimers possessing a repetitive amide-ester coupling sequence

被引：10

作者：

Romagnoli, B

Ashton, PR

Harwood, LM

Philp, D

Price, DW

Smith, MH

Hayes, W

机构：

[1] Univ Reading, Sch Chem, Reading RG6 6AD, Berks, England

[2] Univ Birmingham, Sch Chem Sci, Birmingham B15 2TT, W Midlands, England

[3] Univ St Andrews, Sch Chem, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland

来源：

TETRAHEDRON | 2003年 / 59卷 / 22期

基金：

英国工程与自然科学研究理事会;

关键词：

dendrimer; polyamide; polyester; convergent synthesis;

D O I：

10.1016/S0040-4020(03)00466-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel polyaromatic dendrimers that feature tris-(2-ethylamino)amine as the central core unit has been synthesized up to the third generation by employing a convergent growth strategy. The building blocks 1,3-diamino-2-hydroxypropane and 4-carboxybenzaldehyde were used for dendron construction, a process that involved the cyclic repetition of esterification, oxidation and selective amidation steps. Molecular modelling of this class of dendrimers has been used to predict potential solution state conformations employing molecular mechanics and molecular dynamic simulations. In addition, the results of preliminary metal binding studies using the first generation dendritic system are also outlined. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：3975 / 3988

页数：14

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[11] Combinatorial chemistry for ligand development in catalysis: Synthesis and catalysis screening of peptidosulfonamide tweezers on the solid phase [J].