Colorimetric Logic Gates Based on Supramolecular DNAzyme Structures

被引:120
作者
Bi, Sai [1 ]
Yan, Yameng [1 ]
Hao, Shuangyuan [1 ]
Zhang, Shusheng [1 ]
机构
[1] Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Minist Educ, Key Lab Ecochem Engn, Qingdao 266042, Peoples R China
关键词
aggregation; DNA structures; logic gates; molecular devices; nanoparticles; MOLECULAR COMPUTATION; DNA; NANOPARTICLES; AGGREGATION; ACTIVATION; CIRCUITS; MACHINE; SENSORS;
D O I
10.1002/anie.201000840
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
(Figure Presented) It's logicall A set of DNAzyme-based Boolean logic gates consists of a series of supramolecular structures (see picture). Two metal ions (Mg2+ and Pb2+) act as inputs and gold nanoparticle (AuNP)/ DNA probes as output reporters for colorimetric detection. Fast performance of the logic system at ambient temperature is achieved. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码:4438 / 4442
页数:5
相关论文
共 37 条
[1]   The aggregation of Au nanoparticles by an autonomous DNA machine detects viruses [J].
Beissenhirtz, Moritz K. ;
Elnathan, Roey ;
Weizmann, Yossi ;
Willner, Itamar .
SMALL, 2007, 3 (03) :375-379
[2]   Programmable and autonomous computing machine made of biomolecules [J].
Benenson, Y ;
Paz-Elizur, T ;
Adar, R ;
Keinan, E ;
Livneh, Z ;
Shapiro, E .
NATURE, 2001, 414 (6862) :430-434
[3]   An autonomous molecular computer for logical control of gene expression [J].
Benenson, Y ;
Gil, B ;
Ben-Dor, U ;
Adar, R ;
Shapiro, E .
NATURE, 2004, 429 (6990) :423-429
[4]   Molecular biology - Making catalytic DNAs [J].
Breaker, RR .
SCIENCE, 2000, 290 (5499) :2095-2096
[5]   Molecular computation - Molecular logic gets loaded [J].
De Silva, AP .
NATURE MATERIALS, 2005, 4 (01) :15-16
[6]  
Elbaz J., 2009, ANGEW CHEM, V121, P3892
[7]   Coherent Activation of DNA Tweezers: A "SET-RESET" Logic System [J].
Elbaz, Johann ;
Moshe, Michal ;
Willner, Itamar .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (21) :3834-3837
[8]   Cooperative Multicomponent Self-Assembly of Nucleic Acid Structures for the Activation of DNAzyme Cascades: A Paradigm for DNA Sensors and Aptasensors [J].
Elbaz, Johann ;
Moshe, Michal ;
Shlyahovsky, Bella ;
Willner, Itamar .
CHEMISTRY-A EUROPEAN JOURNAL, 2009, 15 (14) :3411-3418
[9]  
Feng X., 2009, Angew. Chem, V121, P5420
[10]   Fluorescence Logic-Signal-Based Multiplex Detection of Nucleases with the Assembly of a Cationic Conjugated Polymer and Branched DNA [J].
Feng, Xuli ;
Duan, Xinrui ;
Liu, Libing ;
Feng, Fude ;
Wang, Shu ;
Li, Yuliang ;
Zhu, Daoben .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (29) :5316-5321