The fate of the prion protein in the prion/plasminogen complex

被引：32

作者：

Kornblatt, JA

Marchal, S

Rezaei, H

Kornblatt, MJ

Balny, C

Lange, R

Debey, MP

Hoa, GHB

Marden, MC

Grosclaude, J

机构：

[1] Concordia Univ, Montreal, PQ H3G 1M8, Canada

[2] INSERM, Unite 128, F-34293 Montpellier 5, France

[3] INRA, Virol & Immunol Mol, F-78352 Jouy En Josas, France

[4] Museum Natl Hist Nat, INSERM, U565, CARS MNHN,USM0503,UMR8646, F-75005 Paris, France

[5] INSERM, U473, F-94275 Le Kremlin Bicetre, France

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 305卷 / 03期

基金：

加拿大自然科学与工程研究理事会;

关键词：

plasminogen; prion protein; prion cleavage;

D O I：

10.1016/S0006-291X(03)00804-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cellular prion protein (PrPc) forms complexes with plasminogen. Here, we show that the PrPc in this complex is cleaved to yield fragments of PrPc. The cleavage is accelerated by plasmin but does not appear to be dependent on it. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：518 / 522

页数：5

共 32 条

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BACHMANN F, 1994, HAEMOSTASIS THROMBOS, P525

[2] Cellular mechanisms regulating non-haemostatic plasmin generation [J].