A crack in histone lysine methylation

被引：124

作者：

Kubicek, S ^{[1
]}

Jenuwein, T ^{[1
]}

机构：

[1] Vienna Bioctr, Res Inst Mol Pathol, A-1030 Vienna, Austria

来源：

CELL | 2004年 / 119卷 / 07期

关键词：

D O I：

10.1016/j.cell.2004.12.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Histone lysine methylation is regarded as a very stable modification with important functions in epigenetic gene control and for organizing chromatin domains. While more robust modifications of the chromatin template are essential to stabilize epigenetic information, there is now the first evidence for a histone lysine demethylase that reverts an activating methyl mark to the unmodified state (Shi et al., 2004 [this issue of Ceff]).

引用

页码：903 / 906

页数：4

共 19 条

[1] Epigenetic consequences of nucleosome dynamics [J].

Ahmad, K ;

Henikoff, S .

CELL, 2002, 111 (03) :281-284

[2] Histone methylation: Dynamic or static? [J].

Bannister, AJ ;

Schneider, R ;

Kouzarides, T .

CELL, 2002, 109 (07) :801-806

[3] Epigenetic inheritance of active chromatin after removal of the main transactivator [J].

Cavalli, G ;

Paro, R .

SCIENCE, 1999, 286 (5441) :955-958

[4] Histone deimination antagonizes arginine methylation [J].

Cuthbert, GL ;

Daujat, S ;

Snowden, AW ;

Erdjument-Bromage, H ;

Hagiwara, T ;

Yamada, M ;

Schneider, R ;

Gregory, PD ;

Tempst, P ;

Bannister, AJ ;

Kouzarides, T .

CELL, 2004, 118 (05) :545-553

[5] AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli [J].

Falnes, PO ;

Johansen, RF ;

Seeberg, E .

NATURE, 2002, 419 (6903) :178-182

[6] Chromatin compaction by a polycomb group protein complex [J].

Francis, NJ ;

Kingston, RE ;

Woodcock, CL .

SCIENCE, 2004, 306 (5701) :1574-1577

[7] Chromosomal inheritance of epigenetic states in fission yeast during mitosis and meiosis [J].

Grewal, SIS ;

Klar, AJS .

CELL, 1996, 86 (01) :95-101

[8] Translating the histone code [J].

Jenuwein, T ;

Allis, CD .

SCIENCE, 2001, 293 (5532) :1074-1080

[9] Yeast Fms1 is a FAD-utilizing polyamine oxidase [J].

Landry, J ;

Sternglanz, R .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 303 (03) :771-776

[10] Corepressor-dependent silencing of chromosomal regions encoding neuronal genes [J].

Lunyak, VV ;

Burgess, R ;

Prefontaine, GG ;

Nelson, C ;

Sze, SH ;

Chenoweth, J ;

Schwartz, P ;

Pevzner, PA ;

Glass, C ;

Mandel, G ;

Rosenfeld, MG .

SCIENCE, 2002, 298 (5599) :1747-1752

← 1 2 →