Sleep disturbances and dementia risk: A multicenter study

被引：104

作者：

Sindi, Shireen ^{[1
,2
,3
,4
]}

Kareholt, Ingemar ^{[1
,2
,5
]}

Johansson, Lena ^{[4
]}

Skoog, Johan ^{[6
,7
]}

Sjoberg, Linnea ^{[1
,2
]}

Wang, Hui-Xin ^{[1
,2
,8
]}

Johansson, Boo ^{[7
]}

Fratiglioni, Laura ^{[1
,2
,9
]}

Soininen, Hilkka ^{[10
,11
]}

Solomon, Alina ^{[3
,10
]}

Skoog, Ingmar ^{[6
]}

Kivipelto, Miia ^{[3
,4
,10
,12
]}

机构：

[1] Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden

[2] Stockholm Univ, Stockholm, Sweden

[3] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden

[4] Imperial Coll London, Sch Publ Hlth, Neuroepidemiol & Ageing Res Unit, London, England

[5] Jonkoping Univ, Sch Hlth & Welf, Inst Gerontol, Aging Res Network,Jonkoping ARN J, Jonkoping, Sweden

[6] Univ Gothenburg, Sahlgrenska Acad, Ctr Hlth & Ageing AGECAP, Inst Neurosci & Physiol, Gothenburg, Sweden

[7] Univ Gothenburg, Ctr Hlth & Ageing AGECAP, Dept Psychol, Gothenburg, Sweden

[8] Stockholm Univ, Stress Res Inst, Stockholm, Sweden

[9] Stockholm Gerontol Res Ctr, Stockholm, Sweden

[10] Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland

[11] Kuopio Univ Hosp, Neuroctr, Neurol, Kuopio, Finland

[12] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland

来源：

ALZHEIMERS & DEMENTIA | 2018年 / 14卷 / 10期

基金：

芬兰科学院; 瑞典研究理事会;

关键词：

Sleep disturbances; Insomnia; Sleep duration; Dementia; SELF-REPORTED SLEEP; ALZHEIMERS-DISEASE; DAYTIME SLEEPINESS; COGNITIVE DECLINE; INCIDENT DEMENTIA; HEART-DISEASE; DURATION; DISORDERS;

D O I：

10.1016/j.jalz.2018.05.012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Few longitudinal studies assessed whether sleep disturbances are associated with dementia risk. Methods: Sleep disturbances were assessed in three population-based studies (H70 study and Kungsholmen Project [Sweden]; Cardiovascular Risk Factors, Aging and Dementia study [Finland]). Late-life baseline analyses (3-10 years follow-up) used all three studies (N = 1446). Baseline ages 70 years (Cardiovascular Risk Factors, Aging and Dementia, H70), and approximate to 84 years (Kungsholmen Project). Midlife baseline (age approximate to 50 years) analyses used Cardiovascular Risk Factors, Aging and Dementia (21 and 32 years follow-up) (N = 1407). Results: Midlife insomnia (fully adjusted hazard ratio = 1.24, 95% confidence interval = 1.02-1.50) and late-life terminal insomnia (fully adjusted odds ratio = 1.94, 95% confidence interval = 1.08-3.49) were associated with a higher dementia risk. Late-life long sleep duration (>9 hours) was also associated with an increased dementia risk (adjusted odds ratio = 3.98, 95% confidence interval = 1.87-8.48). Discussion: Midlife insomnia and late-life terminal insomnia or long sleep duration were associated with a higher late-life dementia risk. (C) 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：1235 / 1242

页数：8

共 37 条

[11] Sleep disturbance and daytime sleepiness predict vascular dementia [J].

Elwood, Peter C. ;

Bayer, Antony J. ;

Fish, Mark ;

Pickering, Janet ;

Mitchell, Clive ;

Gallacher, John E. J. .

JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, 2011, 65 (09) :820-824

[12] Daytime sleepiness is associated with 3-year incident dementia and cognitive decline in older Japanese-American men [J].

Foley, D ;

Monjan, A ;

Masaki, K ;

Ross, W ;

Havlik, R ;

White, L ;

Launer, L .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2001, 49 (12) :1628-1632

[13] CLINICAL-DIAGNOSIS OF ALZHEIMERS-DISEASE AND OTHER DEMENTIAS IN A POPULATION SURVEY - AGREEMENT AND CAUSES OF DISAGREEMENT IN APPLYING DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL-DISORDERS, REVISED 3RD EDITION, CRITERIA [J].

FRATIGLIONI, L ;

GRUT, M ;

FORSELL, Y ;

VIITANEN, M ;

WINBLAD, B .

ARCHIVES OF NEUROLOGY, 1992, 49 (09) :927-932

[14] Prospective Study of Obstructive Sleep Apnea and Incident Coronary Heart Disease and Heart Failure The Sleep Heart Health Study [J].

Gottlieb, Daniel J. ;

Yenokyan, Gayane ;

Newman, Anne B. ;

O'Connor, George T. ;

Punjabi, Naresh M. ;

Quan, Stuart F. ;

Redline, Susan ;

Resnick, Helaine E. ;

Tong, Elisa K. ;

Diener-West, Marie ;

Shahar, Eyal .

CIRCULATION, 2010, 122 (04) :352-360

[15] Sleep disturbance is associated with cardiovascular and metabolic disorders [J].

Grandner, Michael A. ;

Jackson, Nicholas J. ;

Pak, Victoria M. ;

Gehrman, Philip R. .

JOURNAL OF SLEEP RESEARCH, 2012, 21 (04) :427-433

[16] A Change in Sleep Pattern May Predict Alzheimer Disease [J].

Hahn, Elizabeth A. ;

Wang, Hui-Xin ;

Andel, Ross ;

Fratiglioni, Laura .

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2014, 22 (11) :1262-1271

[17] Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation [J].

Irwin, Michael R. ;

Olmstead, Richard ;

Carroll, Judith E. .

BIOLOGICAL PSYCHIATRY, 2016, 80 (01) :40-52

[18] The Glymphatic System: A Beginner's Guide [J].

Jessen, Nadia Aalling ;

Munk, Anne Sofie Finmann ;

Lundgaard, Iben ;

Nedergaard, Maiken .

NEUROCHEMICAL RESEARCH, 2015, 40 (12) :2583-2599

[19]

Joo EY, 2015, SLEEP MED RES, V6, P50, DOI [DOI 10.17241/SMR.2015.6.2.50, 10.17241/smr.2015.6.2.50]

[20] Sleep Quality and Preclinical Alzheimer Disease [J].

Ju, Yo-El S. ;

McLeland, Jennifer S. ;

Toedebusch, Cristina D. ;

Xiong, Chengjie ;

Fagan, Anne M. ;

Duntley, Stephen P. ;

Morris, John C. ;

Holtzman, David M. .

JAMA NEUROLOGY, 2013, 70 (05) :587-593

← 1 2 3 4 →