Spectrally resolved three-dimensional bioluminescence tomography with a level-set strategy

被引：23

作者：

Liu, Kai ^{[1
]}

Yang, Xin ^{[1
]}

Liu, Dan ^{[1
]}

Qin, Chenghu ^{[1
]}

Liu, Junting ^{[2
]}

Chang, Zhijun ^{[1
]}

Xu, Min ^{[1
]}

Tian, Jie ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Inst Automat, Med Image Proc Grp, Beijing 100190, Peoples R China

[2] Xidian Univ, Life Sci Ctr, Xian 710071, Shaanxi, Peoples R China

来源：

JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION | 2010年 / 27卷 / 06期

基金：

中国国家自然科学基金;

关键词：

RECONSTRUCTION METHOD; OPTICAL TOMOGRAPHY; LIGHT; MODEL; LOOKING; MUMFORD;

D O I：

10.1364/JOSAA.27.001413

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

A reconstruction method is presented for spectrally resolved three-dimensional bioluminescence tomography (BLT) in heterogeneous media using a level-set strategy. In order to reconstruct internal bioluminescent sources, a level-set strategy is utilized to quantitatively localize the distribution of bioluminescent sources. The results in numerical phantom experiments clearly show that the proposed method can tolerate different initial values and noise levels and, furthermore, can work credibly even when the number of phases (levels) is not known a priori. In addition, a mouse atlas reconstruction is employed to demonstrate the effectiveness of the proposed method in turbid mouse geometry. Finally, the physical experiment further evaluates the method's potential in practical applications. (C) 2010 Optical Society of America

引用

页码：1413 / 1423

页数：11

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