The importance of open-source integrative genomics to drug discovery

被引:0
作者
Chesler, Elissa J. [1 ]
Baker, Erich J. [2 ]
机构
[1] Jackson Lab, Bar Harbor, ME 04609 USA
[2] Baylor Univ, Dept Comp Sci, Waco, TX 76798 USA
关键词
Database; data-mining; data sharing; genomics; FUNCTIONAL GENOMICS; MINIMUM INFORMATION; BIOLOGICAL PATHWAYS; ASSOCIATION DATA; GENE-EXPRESSION; SYSTEM; EVOLUTION; DATABASE; PLATFORM; NETWORK;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Researchers investigating many areas of disease recognize the value of integrating large-scale genomic experiments across species and experimental methods. Analysis methods have been developed to make use of the breadth and depth of data from new technologies. Current paradigms of data storage, sharing and analysis are not yet ideal for these purposes. Open-access and analysis-enabled repositories are critical to progress, as they put the global integration of genomic data within reach of individual expert investigators. Current analytic approaches use the full scale and scope of data, but require data sharing, interoperability and community recognition of the value of shared information.
引用
收藏
页码:310 / 316
页数:7
相关论文
共 69 条
[11]  
CORNELIS MC, 2010, GENET EPIDEMIOL, DOI DOI 10.1002/GEPI.20492
[12]   'Omics Data Sharing [J].
Field, Dawn ;
Sansone, Susanna-Assunta ;
Collis, Amanda ;
Booth, Tim ;
Dukes, Peter ;
Gregurick, Susan K. ;
Kennedy, Karen ;
Kolar, Patrik ;
Kolker, Eugene ;
Maxon, Mary ;
Millard, Sian ;
Mugabushaka, Alexis-Michel ;
Perrin, Nicola ;
Remacle, Jacques E. ;
Remington, Karin ;
Rocca-Serra, Philippe ;
Taylor, Chris F. ;
Thorley, Mark ;
Tiwari, Bela ;
Wilbanks, John .
SCIENCE, 2009, 326 (5950) :234-236
[13]   iPHACE: integrative navigation in pharmacological space [J].
Garcia-Serna, Ricard ;
Ursu, Oleg ;
Oprea, Tudor I. ;
Mestres, Jordi .
BIOINFORMATICS, 2010, 26 (07) :985-986
[14]   Galaxy: A platform for interactive large-scale genome analysis [J].
Giardine, B ;
Riemer, C ;
Hardison, RC ;
Burhans, R ;
Elnitski, L ;
Shah, P ;
Zhang, Y ;
Blankenberg, D ;
Albert, I ;
Taylor, J ;
Miller, W ;
Kent, WJ ;
Nekrutenko, A .
GENOME RESEARCH, 2005, 15 (10) :1451-1455
[15]   In silico mapping of complex disease-related traits in mice [J].
Grupe, A ;
Germer, S ;
Usuka, J ;
Aud, D ;
Belknap, JK ;
Klein, RF ;
Ahluwalia, MK ;
Higuchi, R ;
Peltz, G .
SCIENCE, 2001, 292 (5523) :1915-1918
[16]   ERGR: An ethanol-related gene resource [J].
Guo, An-Yuan ;
Webb, Bradley T. ;
Miles, Michael F. ;
Zimmerman, Mark P. ;
Kendler, Kenneth S. ;
Zhao, Zhongming .
NUCLEIC ACIDS RESEARCH, 2009, 37 :D840-D845
[17]   BioMart Central Portal-unified access to biological data [J].
Haider, Syed ;
Ballester, Benoit ;
Smedley, Damian ;
Zhang, Junjun ;
Rice, Peter ;
Kasprzyk, Arek .
NUCLEIC ACIDS RESEARCH, 2009, 37 :W23-W27
[18]   Exploring the functional landscape of gene expression: directed search of large microarray compendia [J].
Hibbs, Matthew A. ;
Hess, David C. ;
Myers, Chad L. ;
Huttenhower, Curtis ;
Li, Kai ;
Troyanskaya, Olga G. .
BIOINFORMATICS, 2007, 23 (20) :2692-2699
[19]  
Huang Da Wei, 2009, Curr Protoc Bioinformatics, VChapter 13, DOI 10.1002/0471250953.bi1311s27
[20]   The systems biology markup language (SBML):: a medium for representation and exchange of biochemical network models [J].
Hucka, M ;
Finney, A ;
Sauro, HM ;
Bolouri, H ;
Doyle, JC ;
Kitano, H ;
Arkin, AP ;
Bornstein, BJ ;
Bray, D ;
Cornish-Bowden, A ;
Cuellar, AA ;
Dronov, S ;
Gilles, ED ;
Ginkel, M ;
Gor, V ;
Goryanin, II ;
Hedley, WJ ;
Hodgman, TC ;
Hofmeyr, JH ;
Hunter, PJ ;
Juty, NS ;
Kasberger, JL ;
Kremling, A ;
Kummer, U ;
Le Novère, N ;
Loew, LM ;
Lucio, D ;
Mendes, P ;
Minch, E ;
Mjolsness, ED ;
Nakayama, Y ;
Nelson, MR ;
Nielsen, PF ;
Sakurada, T ;
Schaff, JC ;
Shapiro, BE ;
Shimizu, TS ;
Spence, HD ;
Stelling, J ;
Takahashi, K ;
Tomita, M ;
Wagner, J ;
Wang, J .
BIOINFORMATICS, 2003, 19 (04) :524-531