Guggullipid derivatives: synthesis and applications

被引：5

作者：

Ahmad, Moghis U. ^{[1
]}

Ali, Shoukath M. ^{[1
]}

Ahmad, Ateeq ^{[1
]}

Sheikh, Saifuddin ^{[1
]}

Ahmad, Imran ^{[1
]}

机构：

[1] Jina Pharmaceut Inc, Libertyville, IL 60048 USA

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 2010年 / 163卷 / 4-5期

关键词：

Guggullipid; Synthesis; Liposome; Drug delivery; IIA SECRETORY PHOSPHOLIPASE-A2; AYURVEDIC CRUDE DRUGS; COMMIPHORA-MUKUL; STEREOCHEMISTRY; DOXORUBICIN; EXPRESSION; CHEMISTRY; LEUKEMIA; CANCER; RESIN;

D O I：

10.1016/j.chemphyslip.2010.02.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two guggullipid derivatives,Z-guggulsulfate [4,17(20)-pregnadiene-3-one-16 beta-sulfate] sodium salt and Z-guggullaurate (4,17(20)-pregnadiene-3-one-16 beta-laurate], have been synthesized and evaluated for liposomal drug delivery system. Its precursor, Z-guggulsterol [4,17(20)-pregnadiene-3-one-16 beta-ol], is also synthesized in gram scale starting from guggulsterone using the novel combination of known reactions in fewer steps and with higher yield than previously reported synthesis. These new synthetic guggullipid derivatives were also used in the preparation of liposomes. This new class of lipid molecules will be a useful tool in the development of nanosomal or liposomal drug delivery system. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：362 / 366

页数：5

共 14 条

[1]

Abe T, 1997, INT J CANCER, V74, P245, DOI 10.1002/(SICI)1097-0215(19970620)74:3<245::AID-IJC2>3.0.CO

[2]

2-Z

[3] CHEMISTRY OF AYURVEDIC CRUDE DRUGS .5. GUGGULU (RESIN FROM COMMIPHORA-MUKUL) .5. SOME NEW STEROIDAL COMPONENTS AND, STEREOCHEMISTRY OF GUGGULSTEROL-I AT C-20 AND C-22 [J].