Intraoperative Prediction Of Non-Sentinel Lymph Node Metastasis Based On The Molecular Assay In Breast Cancer Patients

被引：7

作者：

Sun, Xiao ^{[1
]}

Zhang, Yan ^{[2
]}

Wu, Shuang ^{[1
]}

Fu, Li ^{[3
]}

Yun, Jing-Ping ^{[4
]}

Wang, Yong-Sheng ^{[1
]}

机构：

[1] Shandong First Med Univ & Shandong Acad Med Sci, Shandong Univ, Shandong Canc Hosp & Inst, Breast Canc Ctr, Jinan, Shandong, Peoples R China

[2] Zibo Cent Hosp, Dept Breast & Thyroid Surg, Zibo, Peoples R China

[3] Tianjin Med Univ, Canc Hosp, Dept Pathol, Tianjin, Peoples R China

[4] Sun Yat Sen Univ, Canc Ctr, Dept Pathol, Guangzhou, Guangdong, Peoples R China

来源：

CANCER MANAGEMENT AND RESEARCH | 2019年 / 11卷

关键词：

breast neoplasm; molecular diagnostic techniques; nomograms; sentinel lymph node biopsy; ACID AMPLIFICATION ASSAY; MULTICENTER; VALIDATION; BIOPSY; IRRADIATION; NOMOGRAM; AXILLA; MODELS; WOMEN;

D O I：

10.2147/CMAR.S226733

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: The aim of the study is to construct an intraoperative nomogram for the prediction of non-sentinel lymph node (NSLN) metastasis based on the one-step nucleic acid amplification assay in breast cancer patients. Methods: A total of 552 patients were enrolled in the training study and 1090 patients were enrolled in the validation study. The nomogram was constructed based on the molecular assay with logistic multivariate regression analysis in the training study and was validated in the validation study. Results: A novel nomogram model was constructed with the total tumor load, the clinical primary tumor size, the number of positive and negative sentinel lymph nodes. The area under the receiver operating characteristic curve (AUC) of the model was 0.842. The AUC of the model which was sensitive to discern the patients with the stage of pN1 and >= pN2 was 0.861. Conclusion: The nomogram model will help to guide the axillary management intraoperatively and precisely confirm the target region of radiotherapy postoperatively.

引用

页码：9715 / 9723

页数：9

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