Intraoperative Prediction Of Non-Sentinel Lymph Node Metastasis Based On The Molecular Assay In Breast Cancer Patients

被引:7
作者
Sun, Xiao [1 ]
Zhang, Yan [2 ]
Wu, Shuang [1 ]
Fu, Li [3 ]
Yun, Jing-Ping [4 ]
Wang, Yong-Sheng [1 ]
机构
[1] Shandong First Med Univ & Shandong Acad Med Sci, Shandong Univ, Shandong Canc Hosp & Inst, Breast Canc Ctr, Jinan, Shandong, Peoples R China
[2] Zibo Cent Hosp, Dept Breast & Thyroid Surg, Zibo, Peoples R China
[3] Tianjin Med Univ, Canc Hosp, Dept Pathol, Tianjin, Peoples R China
[4] Sun Yat Sen Univ, Canc Ctr, Dept Pathol, Guangzhou, Guangdong, Peoples R China
来源
CANCER MANAGEMENT AND RESEARCH | 2019年 / 11卷
关键词
breast neoplasm; molecular diagnostic techniques; nomograms; sentinel lymph node biopsy; ACID AMPLIFICATION ASSAY; MULTICENTER; VALIDATION; BIOPSY; IRRADIATION; NOMOGRAM; AXILLA; MODELS; WOMEN;
D O I
10.2147/CMAR.S226733
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: The aim of the study is to construct an intraoperative nomogram for the prediction of non-sentinel lymph node (NSLN) metastasis based on the one-step nucleic acid amplification assay in breast cancer patients. Methods: A total of 552 patients were enrolled in the training study and 1090 patients were enrolled in the validation study. The nomogram was constructed based on the molecular assay with logistic multivariate regression analysis in the training study and was validated in the validation study. Results: A novel nomogram model was constructed with the total tumor load, the clinical primary tumor size, the number of positive and negative sentinel lymph nodes. The area under the receiver operating characteristic curve (AUC) of the model was 0.842. The AUC of the model which was sensitive to discern the patients with the stage of pN1 and >= pN2 was 0.861. Conclusion: The nomogram model will help to guide the axillary management intraoperatively and precisely confirm the target region of radiotherapy postoperatively.
引用
收藏
页码:9715 / 9723
页数:9
相关论文
共 25 条
[11]   New models and online calculator for predicting non-sentinel lymph node status in sentinel lymph node positive breast cancer patients [J].
Kohrt, Holbrook E. ;
Olshen, Richard A. ;
Bermas, Honnie R. ;
Goodson, William H. ;
Wood, Douglas J. ;
Henry, Solomon ;
Rouse, Robert V. ;
Bailey, Lisa ;
Philben, Vicki J. ;
Dirbas, Frederick M. ;
Dunn, Jocelyn J. ;
Johnson, Denise L. ;
Wapnir, Irene L. ;
Carlson, Robert W. ;
Stockdale, Frank E. ;
Hansen, Nora M. ;
Jeffrey, Stefanie S. .
BMC CANCER, 2008, 8 (1)
[12]   Validation of a breast cancer nomogram for predicting nonsentinel lymph node metastases after a positive sentinel node biopsy [J].
Lambert, LA ;
Ayers, GD ;
Hwang, RF ;
Hunt, KK ;
Ross, MI ;
Kuerer, HM ;
Singletary, SE ;
Babiera, GV ;
Ames, FC ;
Feig, B ;
Lucci, A ;
Krishnamurthy, S ;
Meric-Bernstam, F .
ANNALS OF SURGICAL ONCOLOGY, 2006, 13 (03) :310-320
[13]   Sentinel Lymph Node Biopsy for Patients With Early-Stage Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update [J].
Lyman, Gary H. ;
Somerfield, Mark R. ;
Bosserman, Linda D. ;
Perkins, Cheryl L. ;
Weaver, Donald L. ;
Giuliano, Armando E. .
JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (05) :561-+
[14]   International Multicenter Tool to Predict the Risk of Nonsentinel Node Metastases in Breast Cancer [J].
Meretoja, Tuomo J. ;
Leidenius, Marjut H. K. ;
Heikkila, Paivi S. ;
Boross, Gabor ;
Sejben, Istvan ;
Regitnig, Peter ;
Luschin-Ebengreuth, Gero ;
Zgajnar, Janez ;
Perhavec, Andraz ;
Gazic, Barbara ;
Lazar, Gyorgy ;
Takacs, Tibor ;
Voros, Andras ;
Saidan, Zuhair A. ;
Nadeem, Rana M. ;
Castellano, Isabella ;
Sapino, Anna ;
Bianchi, Simonetta ;
Vezzosi, Vania ;
Barranger, Emmanuel ;
Lousquy, Ruben ;
Arisio, Riccardo ;
Foschini, Maria Pia ;
Imoto, Shigeru ;
Kamma, Hiroshi ;
Tvedskov, Tove F. ;
Kroman, Niels ;
Jensen, Maj-Brit ;
Audisio, Riccardo A. ;
Cserni, Gabor .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2012, 104 (24) :1888-1896
[15]   A model for predicting non-sentinel lymph node metastatic disease when the sentinel lymph node is positive [J].
Pal, A. ;
Provenzano, E. ;
Duffy, S. W. ;
Pinderl, S. E. ;
Purushotham, A. D. .
BRITISH JOURNAL OF SURGERY, 2008, 95 (03) :302-309
[16]   Internal Mammary and Medial Supraclavicular Irradiation in Breast Cancer [J].
Poortmans, P. M. ;
Collette, S. ;
Kirkove, C. ;
Van Limbergen, E. ;
Budach, V. ;
Struikmans, H. ;
Collette, L. ;
Fourquet, A. ;
Maingon, P. ;
Valli, M. ;
De Winter, K. ;
Marnitz, S. ;
Barillot, I. ;
Scandolaro, L. ;
Vonk, E. ;
Rodenhuis, C. ;
Marsiglia, H. ;
Weidner, N. ;
van Tienhoven, G. ;
Glanzmann, C. ;
Kuten, A. ;
Arriagada, R. ;
Bartelink, H. ;
van den Bogaert, W. .
NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (04) :317-327
[17]   One-step nucleic acid amplification-a molecular method for the detection of lymph node metastases in breast cancer patients; results of the German study group [J].
Schem, Christian ;
Maass, Nicolai ;
Bauerschlag, Dirk O. ;
Carstensen, Martin H. ;
Loning, Thomas ;
Roder, Christian ;
Batic, Olivera ;
Jonat, Walter ;
Tiemann, Katharina .
VIRCHOWS ARCHIV, 2009, 454 (02) :203-210
[18]   Proceedings of the Consensus Conference on the Role of Sentinel Lymph Node Biopsy in Carcinoma of the Breast, April 19-22, 2001, Philadelphia, Pennsylvania [J].
Schwartz, GF ;
Giuliano, AE ;
Veronesi, U .
CANCER, 2002, 94 (10) :2542-2551
[19]   One-step nucleic acid amplification assay is an accurate technique for sentinel lymph node biopsy of breast cancer patients: a meta-analysis [J].
Shi, Fang ;
Zhang, Qian ;
Liang, Zhenzhen ;
Zhang, Mengmeng ;
Liu, Xin .
BRITISH JOURNAL OF CANCER, 2017, 117 (08) :1185-1191
[20]   Molecular Detection of Lymph Node Metastases in Breast Cancer Patients: Results of a Multicenter Trial Using the One-Step Nucleic Acid Amplification Assay [J].
Tamaki, Yasuhiro ;
Akiyama, Futoshi ;
Iwase, Takuji ;
Kaneko, Tomoyo ;
Tsuda, Hitoshi ;
Sato, Kazuhiko ;
Ueda, Shigeto ;
Mano, Masayuki ;
Masuda, Norikazu ;
Takeda, Masashi ;
Tsujimoto, Masahiko ;
Yoshidome, Katsuhide ;
Inaji, Hideo ;
Nakajima, Hiromu ;
Komoike, Yoshifumi ;
Kataoka, Tatsuki R. ;
Nakamura, Seigo ;
Suzuki, Koyu ;
Tsugawa, Koichiro ;
Wakasa, Kenichi ;
Okino, Tsuyoshi ;
Kato, Yo ;
Noguchi, Shinzaburo ;
Matsuura, Nariaki .
CLINICAL CANCER RESEARCH, 2009, 15 (08) :2879-2884