Chemokines and hepatocellular carcinoma

被引：57

作者：

Huang, Fan ^{[1
]}

Geng, Xiao-Ping ^{[1
]}

机构：

[1] Anhui Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Hefei 230022, Anhui, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2010年 / 16卷 / 15期

关键词：

Chemokines; Hepatocellular carcinoma; FACTOR-I; RECEPTOR CXCR4; HEPATOMA-CELLS; NONSMALL CELL; EXPRESSION; CANCER; LIVER; LIGAND; GROWTH; INFLAMMATION;

D O I：

10.3748/wjg.v16.i15.1832

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Chemokines play a paramount role in tumor progression. In hepatocellular carcinoma (HCC) progression, chemokines and their receptors play an intricate role. Currently, chemokines and their receptors such as the CXCL12-CXCR4 axis, CX3CL1-CX3CR1 axis and the CCL20-CCR6 axis have received much research attention. Although a large number of studies show that these axes are strongly associated with HCC, the exact mechanism by which these axes promote the growth and progression of HCC remains unknown. In this paper, several chemokines and their receptor interactions in HCC progression, growth and metastasis and immune response to HCC are reviewed. (C) 2010 Baishideng. All rights reserved.

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页码：1832 / 1836

页数：5

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