Long non-coding RNA SMASR inhibits the EMT by negatively regulating TGF-β/Smad signaling pathway in lung cancer

被引：30
|
作者：
Xu, Lele [1 ]
Liu, Wenzhong [1 ]
Li, Tongtong [1 ]
Hu, Yuying [2 ]
Wang, Yu [1 ]
Huang, Lijie [1 ]
Wang, Yan [2 ]
Shao, Shujuan [3 ]
Liu, Xuefeng [1 ]
Zhan, Qimin [1 ,2 ]
机构：
[1] Dalian Med Univ, Inst Canc Stern Cell, Dalian, Peoples R China
[2] Peking Univ Canc Hosp & Inst, Lab Mol Oncol, Minist Educ Beijing, Key Lab Carcinogenesis & Translat Res, Beijing, Peoples R China
[3] Dalian Med Univ, Liaoning Key Lab Prote, Dalian, Peoples R China
来源：
ONCOGENE | 2021年 / 40卷 / 20期
基金：
中国国家自然科学基金;
关键词：
EPITHELIAL-MESENCHYMAL TRANSITION; LNCRNA; METASTASIS; EXPRESSION; PROMOTES; REPRESSION; INTERACTS; TARGET; CELLS; MYC;
D O I：
10.1038/s41388-021-01760-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
TGF-beta/Smad signaling pathway plays an important role in EMT during cancer progression. Long non-coding RNAs (lncRNAs) are involved in various behaviors of cancer cells, including EMT. Here, we report a novel lncRNA adjacent to Smad3, named Smad3-associated long non-coding RNA (SMASR). SMASR is downregulated by TGF-beta via Smad2/3 in lung cancer cells. Knockdown of SMASR induces EMT and increases the migration and invasion of lung cancer cells. Moreover, knockdown of SMASR promotes the phosphorylation of Smad2/3. Mechanistically, SMASR interacts with Smad2/3 and inhibits the expression of TGFBR1, the TGF-beta type I receptor responsible for phosphorylation of Smad2/3, thus leading to inactivation of TGF-beta/Smad signaling pathway. Clinically, SMASR is downregulated in lung cancer tissues. Collectively, our findings prove a critical role of SMASR in EMT of lung cancer by forming a negative feedback loop with TGF-beta/Smad signaling pathway.
引用
收藏
页码：3578 / 3592
页数：15
相关论文
共 50 条
  • [1] Long non-coding RNA SMASR inhibits the EMT by negatively regulating TGF-β/Smad signaling pathway in lung cancer
    Lele Xu
    Wenzhong Liu
    Tongtong Li
    Yuying Hu
    Yu Wang
    Lijie Huang
    Yan Wang
    Shujuan Shao
    Xuefeng Liu
    Qimin Zhan
    Oncogene, 2021, 40 : 3578 - 3592
  • [2] RNA demethylase ALKBH5 inhibits TGF-β-induced EMT by regulating TGF-β/SMAD signaling in non-small cell lung cancer
    Sun, Zelong
    Su, Zhiyue
    Zhou, Zhengyu
    Wang, Shengjie
    Wang, Zhao
    Tong, Xin
    Li, Chang
    Wang, Yuxin
    Chen, Xiaoyan
    Lei, Zhe
    Zhang, Hong-Tao
    FASEB JOURNAL, 2022, 36 (05):
  • [3] Long non-coding RNA ANRIL promotes the invasion and metastasis of thyroid cancer cells through TGF-β/Smad signaling pathway
    Zhao, Jian-Jie
    Hao, Shuai
    Wang, Ling-Li
    Hu, Chun-Yan
    Zhang, Shu
    Guo, Ling-Ji
    Zhang, Gang
    Gao, Bo
    Jiang, Yan
    Tian, Wu-Guo
    Luo, Dong-Lin
    ONCOTARGET, 2016, 7 (36) : 57903 - 57918
  • [4] Long non-coding RNA CCAT2 promotes the breast cancer growth and metastasis by regulating TGF-β signaling pathway
    Wu, Z. -J.
    Li, Y.
    Wu, Y. -Z.
    Wang, Y.
    Nian, W. -Q.
    Wang, L. -L.
    Li, L. -C.
    Luo, H. -L.
    Wang, D. -L.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2017, 21 (04) : 706 - 714
  • [5] Long non-coding RNAs and TGF-β signaling in cancer
    Papoutsoglou, Panagiotis
    Moustakas, Aristidis
    CANCER SCIENCE, 2020, 111 (08) : 2672 - 2681
  • [6] Long non-coding RNA GAS5 contributed to the development of glaucoma via regulating the TGF-β signaling pathway
    Xu, Y.
    Xing, Y. -Q.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2018, 22 (04) : 896 - 902
  • [7] Long noncoding RNA lnc-TSI inhibits renal fibrogenesis by negatively regulating the TGF-β/Smad3 pathway
    Wang, Peng
    Luo, Man-Li
    Song, Erwei
    Zhou, Zhanmei
    Ma, Tongtong
    Wang, Jun
    Jia, Nan
    Wang, Guobao
    Nie, Sheng
    Liu, Youhua
    Hou, FanFan
    SCIENCE TRANSLATIONAL MEDICINE, 2018, 10 (462)
  • [8] Long non-coding RNA LICPAR regulates atrial fibrosis via TGF-β/Smad pathway in atrial fibrillation
    Wang, Haiyan
    Song, Tingting
    Zhao, Ying
    Zhao, Jiayu
    Wang, Xun
    Fu, Xianghua
    TISSUE & CELL, 2020, 67
  • [9] High long non-coding RNA NORAD expression predicts poor prognosis and promotes breast cancer progression by regulating TGF-β pathway
    Ke Zhou
    Qin Ou
    Geng Wang
    Wenqi Zhang
    Yin Hao
    Wenfang Li
    Cancer Cell International, 19
  • [10] Long Non-Coding RNA DANCR Synergizes With IGF2BP2 to Attenuate Diabetic Kidney Disease Induced Glomerulosclerosis by Negatively Regulating the TGF-β/Smad3 Pathway
    Liu, Feng
    Zhang, Chun
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2022, 33 (11): : 666 - 666
12345