Glucose oxidase mediated targeted cancer-starving therapy by biotinylated self-assembled vesicles

被引：69

作者：

Dinda, Soumik ^{[1
]}

Sarkar, Saheli ^{[1
]}

Das, Prasanta Kumar ^{[1
]}

机构：

[1] Indian Assoc Cultivat Sci, Dept Biol Chem, Kolkata 700032, India

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 71期

关键词：

HYDROGEN-PEROXIDE; MELANOMA; DELIVERY; CELLS; CHEMOTHERAPY; AMPHIPHILE; TUMORS;

D O I：

10.1039/c8cc03599g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we demonstrate glucose oxidase (GOx) mediated targeted cancer-starving therapy by self-assembled vesicle of trimesic acid based biotinylated amphiphile (TMB). The TMB vesicles entrapped GOx and selectively killed cancer cells (HeLa, B16F10), with similar to 6-fold higher efficiency compared to non-cancer cells (CHO, NIH3T3), by blocking the energy supply to tumors through the oxidation of intracellular glucose.

引用

页码：9929 / 9932

页数：4

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