MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues

被引：58

作者：

Gonzalez-Molina, Jordi ^{[1
,2
]}

Gramolelli, Silvia ^{[3
]}

Liao, Zehuan ^{[1
,4
]}

Carlson, Joseph W. ^{[2
]}

Ojala, Paivi M. ^{[3
,5
]}

Lehti, Kaisa ^{[1
,6
]}

机构：

[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, S-17177 Stockholm, Sweden

[2] Karolinska Inst, Dept Oncol Pathol, S-17176 Stockholm, Sweden

[3] Univ Helsinki, Fac Med, Translat Canc Med Res Program, FIN-00014 Helsinki, Finland

[4] Nanyang Technol Univ Singapore, Sch Biol Sci, 60 Nanyang Dr, Singapore 637551, Singapore

[5] Imperial Coll London, Dept Med, Div Infect Dis, Sect Virol, London W2 1NY, England

[6] Univ Helsinki, Fac Med, Individualized Drug Therapy Res Program, FIN-00014 Helsinki, Finland

来源：

CELLS | 2019年 / 8卷 / 09期

基金：

瑞典研究理事会;

关键词：

MMP14; sarcoma; tumor microenvironment; mesenchymal phenotype; metastasis; TYPE-1; MATRIX-METALLOPROTEINASE; EPITHELIAL-MESENCHYMAL TRANSITION; EXTRACELLULAR-MATRIX; CELL INVASION; IN-VIVO; 1-MATRIX METALLOPROTEINASE; INTRACELLULAR ACTIVATION; OSTEOSARCOMA CELLS; MMP-2; ACTIVATION; MAPK ACTIVATION;

D O I：

10.3390/cells8090991

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sarcomas are deadly malignant tumors of mesenchymal origin occurring at all ages. The expression and function of the membrane-type matrix metalloproteinase MMP14 is closely related to the mesenchymal cell phenotype, and it is highly expressed in most sarcomas. MMP14 regulates the activity of multiple extracellular and plasma membrane proteins, influencing cell-cell and cell-extracellular matrix (ECM) communication. This regulation mediates processes such as ECM degradation and remodeling, cell invasion, and cancer metastasis. Thus, a comprehensive understanding of the biology of MMP14 in sarcomas will shed light on the mechanisms controlling the key processes in these diseases. Here, we provide an overview of the function and regulation of MMP14 and we discuss their relationship with clinical and pre-clinical MMP14 data in both adult and childhood sarcomas.

引用

页数：24

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