Childhood MS and ADEM: Investigation and Comparison of Neurocognitive Features in Children

被引：22
作者：
Deery, Ben [2 ,3 ]
Anderson, Vicki [1 ,2 ,3 ]
Jacobs, Rani [2 ,3 ]
Neale, Jenny [3 ,4 ]
Kornberg, Andrew [3 ,4 ]
机构：
[1] Royal Childrens Hosp, Dept Psychol, Parkville, Vic 3052, Australia
[2] Univ Melbourne, Melbourne, Vic, Australia
[3] Murdoch Childrens Res Inst, Melbourne, Vic, Australia
[4] Royal Childrens Hosp, Dept Neurosci, Parkville, Vic 3052, Australia
来源：
DEVELOPMENTAL NEUROPSYCHOLOGY | 2010年 / 35卷 / 05期
关键词：
ACUTE DISSEMINATED ENCEPHALOMYELITIS; EARLY-TREATED PHENYLKETONURIA; MULTIPLE-SCLEROSIS; EXECUTIVE FUNCTION; DIFFUSION TENSOR; WHITE-MATTER; MAGNETIZATION-TRANSFER; COGNITIVE IMPAIRMENT; BACTERIAL-MENINGITIS; DIAGNOSTIC-CRITERIA;
D O I：
10.1080/87565641.2010.494921
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
Cognitive deficits in adult multiple sclerosis (MS) are well documented; however, little is known regarding cognitive impairments in similar childhood conditions. This study compared cognitive profiles of children aged 7-18 years with MS (N = 9) to those with acute disseminated encephalomyelitis (ADEM) (N = 9), a similar but monophasic condition. Individual profiles showed clinically relevant impairments across all cognitive domains evaluated. Differences in severity and spread were also found. Results suggest a gradient effect, with the transient white matter disruption in ADEM resulting in subtle cognitive impairments, while the multiple insults to white matter in childhood MS are associated with more severe sequelae.
引用
收藏
页码：506 / 521
页数：16
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