Experimental and theoretical study on the supramolecular complexes of 15-crown-5 with adrenaline

被引：5

作者：

Liu, Tao ^{[2
,3
]}

Yu, Zhang-Yu ^{[1
,3
,4
]}

机构：

[1] Shandong Univ, Sch Chem & Chem Engn, Jinan 250010, Shandong, Peoples R China

[2] Jining Univ, Dept Chem & Chem Engn, Qufu 273155, Shandong, Peoples R China

[3] Qufu Normal Univ, Dept Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China

[4] Heze Univ, Dept Chem & Chem Engn, Heze 274015, Shandong, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 16期

基金：

中国博士后科学基金;

关键词：

Adrenaline; 15-crown-5; Supramolecular complex; Cyclic voltammetry; B3LYP; ELECTROCHEMICAL-BEHAVIOR; RECOGNITION; RECEPTORS; 18-CROWN-6; CATECHOLAMINES; EPINEPHRINE; POLYETHERS; POTENTIALS; CONTINUUM; ELECTRODE;

D O I：

10.1016/j.bmcl.2010.06.098

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The electron transfer properties of supramolecular complexes of 15-crown-5 (15C5) with protonated adrenaline (PAd(+)) at different electrodes using cyclic voltammetry (CV) have been investigated in the article. The experimental results show that 15C5 will affect the electron transfer properties of adrenaline. The formed supramolecular complexes by ion-dipole and hydrogen bond interaction between PAd(+) and 15C5 will slow down the diffusion ability of adrenaline and make it hard to donate electron and be oxidized. The interaction energies and NPA calculations for the supramolecular complexes of 15C5 with PAd(+) at B3LYP/6-31+G(d) level have been performed. The calculational results confirm the experimental fact that 15C5 can form stable supramolecular complexes with PAd(+). (c) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4845 / 4849

页数：5

共 42 条

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