Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea

被引：169

作者：

Dabdoub, A ^{[1
]}

Donohue, MJ

Brennan, A

Wolf, V

Montcouquiol, M

Sassoon, DA

Hseih, JC

Rubin, JS

Salinas, PC

Kelley, MW

机构：

[1] NIDCD, Sect Dev Neurosci, NIH, Rockville, MD 20850 USA

[2] Univ London Imperial Coll Sci Technol & Med, Dept Biol Sci, London SW7 2AZ, England

[3] NCI, Cellular & Mol Biol Lab, Div Basic Sci, NIH, Bethesda, MD 20892 USA

[4] Mt Sinai Sch Med, Dept Biochem & Mol Biol, New York, NY 10029 USA

[5] SUNY Stony Brook, Dept Biochem & Cell Biol, Stony Brook, NY 11794 USA

来源：

DEVELOPMENT | 2003年 / 130卷 / 11期

关键词：

planar polarity; organ of Corti; sensory epithelium; mechanosensory hair cells; mouse;

D O I：

10.1242/dev.00448

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In the mammalian cochlea, stereociliary bundles located on mechanosensory hair cells within the sensory epithelium are unidirectionally oriented. Development of this planar polarity is necessary for normal hearing as stereociliary bundles are only sensitive to vibrations in a single plane; however, the mechanisms governing their orientation are unknown. We report that Wnt signaling regulates the development of unidirectional stereociliary bundle orientation. In vitro application of Wnt7a protein or inhibitors of Wnt signaling, secreted Frizzled-related protein 1 or Wnt inhibitory factor 1, disrupts bundle orientation. Moreover, Wnt7a is expressed in a pattern consistent with a role in the polarization of the developing stereociliary bundles. We propose that Wnt signaling across the region of developing outer hair cells gives rise to planar polarity in the mammalian cochlea.

引用

页码：2375 / 2384

页数：10