Transplantation in Acute Myeloid Leukemia

被引：10

作者：

Zuckerman, Tsila ^{[1
,2
]}

Rowe, Jacob M. ^{[1
,2
,3
]}

机构：

[1] Dept Hematol & Bone Marrow Transplantat, IL-3525408 Haifa, Israel

[2] Technion Israel Inst Technol, Bruce Rappaport Fac Med, IL-31096 Haifa, Israel

[3] Shaare Zedek Med Ctr, Dept Hematol, IL-9102102 Jerusalem, Israel

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2014年 / 28卷 / 06期

关键词：

Acute myeloid leukemia; Allogeneic stem cell transplantation; Autologous stem cell transplantation; Complete remission; Genetic alterations; STEM-CELL TRANSPLANTATION; ACUTE MYELOGENOUS LEUKEMIA; 1ST COMPLETE REMISSION; INTERNAL TANDEM DUPLICATION; MATCHED UNRELATED DONORS; REDUCED-INTENSITY; HEMATOPOIETIC TRANSPLANTATION; MONOSOMAL KARYOTYPE; ALLOGENEIC TRANSPLANTATION; PROGNOSTIC-FACTORS;

D O I：

10.1016/j.hoc.2014.08.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acute myeloid leukemia (AML) is associated with poor outcome mainly because of relapse. The best antileukemic treatment is allogeneic stem cell transplantation. However, the associated significant nonrelapse mortality limits both the application and outcome of the procedure. Recent advances in understanding the genetic landscape of the disease enable educated selection of patients. Improved treatment protocols, supportive therapy, patient selection, and posttransplant manipulations all contribute to a better outcome.

引用

页码：983 / +

页数：13

共 54 条

[1] Pre-transplant MRD predicts outcome following reduced-intensity and myeloablative allogeneic hemopoietic SCT in AML [J].

Anthias, C. ;

Dignan, F. L. ;

Morilla, R. ;

Morilla, A. ;

Ethell, M. E. ;

Potter, M. N. ;

Shaw, B. E. .

BONE MARROW TRANSPLANTATION, 2014, 49 (05) :679-683

[2] Improved outcome after stem-cell transplantation in FLT3/ITD-positive AML [J].

Bornhaeuser, Martin ;

Illmer, Thomas ;

Schaich, Markus ;

Soucek, Silke ;

Ehninger, Gerhard ;

Thiede, Christian .

BLOOD, 2007, 109 (05) :2264-2265

[3] Prognostic index for adult patients with acute myeloid leukemia in first relapse [J].

Breems, DA ;

Van Putten, WLJ ;

Huijgens, PC ;

Ossenkoppele, GJ ;

Verhoef, GEG ;

Verdonck, LF ;

Vellenga, E ;

De Greef, G ;

Jacky, E ;

Van der Lelie, J ;

Boogaerts, MA ;

Löwenberg, B .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (09) :1969-1978

[4] Hematopoietic transplantation for acute myeloid leukemia with internal tandem duplication of FLT3 gene (FLT3/ITD) [J].

Brunet, Salut ;

Martino, Rodrigo ;

Sierra, Jorge .

CURRENT OPINION IN ONCOLOGY, 2013, 25 (02) :195-204

[5] Impact of FLT3 Internal Tandem Duplication on the Outcome of Related and Unrelated Hematopoietic Transplantation for Adult Acute Myeloid Leukemia in First Remission: A Retrospective Analysis [J].

Brunet, Salut ;

Labopin, Myriam ;

Esteve, Jordi ;

Cornelissen, Jan ;

Socie, Gerard ;

Iori, Anna P. ;

Verdonck, Leo F. ;

Volin, Liisa ;

Gratwohl, Alois ;

Sierra, Jorge ;

Mohty, Mohamad ;

Rocha, Vanderson .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (07) :735-741

[6] Curability of Patients With Acute Myeloid Leukemia Who Did Not Undergo Transplantation in First Remission [J].

Burnett, Alan K. ;

Goldstone, Anthony ;

Hills, Robert K. ;

Milligan, Donald ;

Prentice, Archie ;

Yin, John ;

Wheatley, Keith ;

Hunter, Ann ;

Russell, Nigel .

JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (10) :1293-1301

[7] Reduced intensity allogeneic hematopoietic transplantation is an established standard of care for treatment of older patients with acute myeloid leukemia [J].

Champlin, Richard .

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 2013, 26 (03) :297-300

[8] Better leukemia-free and overall survival in AML in first remission following cyclophosphamide in combination with busulfan compared with TBI [J].

Copelan, Edward A. ;

Hamilton, Betty K. ;

Avalos, Belinda ;

Ahn, Kwang Woo ;

Bolwell, Brian J. ;

Zhu, Xiaochun ;

Aljurf, Mahmoud ;

van Besien, Koen ;

Bredeson, Christopher ;

Cahn, Jean-Yves ;

Costa, Luciano J. ;

de Lima, Marcos ;

Gale, Robert Peter ;

Hale, Gregory A. ;

Halter, Joerg ;

Hamadani, Mehdi ;

Inamoto, Yoshihiro ;

Kamble, Rammurti T. ;

Litzow, Mark R. ;

Loren, Alison W. ;

Marks, David I. ;

Olavarria, Eduardo ;

Roy, Vivek ;

Sabloff, Mitchell ;

Savani, Bipin N. ;

Seftel, Matthew ;

Schouten, Harry C. ;

Ustun, Celalettin ;

Waller, Edmund K. ;

Weisdorf, Daniel J. ;

Wirk, Baldeep ;

Horowitz, Mary M. ;

Arora, Mukta ;

Szer, Jeff ;

Cortes, Jorge ;

Kalaycio, Matt E. ;

Maziarz, Richard T. ;

Saber, Wael .

BLOOD, 2013, 122 (24) :3863-3870

[9] Results of a HOVON/SAKK donor versus no-donor analysis of myeloablative HLA-identical sibling stem cell transplantation in first remission acute myeloid leukemia in young and middle-aged adults: benefits for whom? [J].

Cornelissen, Jan J. ;

van Putten, Wim L. J. ;

Verdonck, Leo F. ;

Theobald, Matthias ;

Jacky, Emanuel ;

Daenen, Simon M. G. ;

Kooy, Marinus van Marwijk ;

Wijermans, Pierre ;

Schouten, Harry ;

Huijgens, Peter C. ;

van der Lelie, Hans ;

Fey, Martin ;

Ferrant, Augustin ;

Maertens, Johan ;

Gratwohl, Alois ;

Lowenberg, Bob .

BLOOD, 2007, 109 (09) :3658-3666

[10] Comparative Analysis of the Value of Allogeneic Hematopoietic Stem-Cell Transplantation in Acute Myeloid Leukemia With Monosomal Karyotype Versus Other Cytogenetic Risk Categories [J].

Cornelissen, Jan J. ;

Breems, Dimitri ;

van Putten, Wim L. J. ;

Gratwohl, Alois A. ;

Passweg, Jakob R. ;

Pabst, Thomas ;

Maertens, Johan ;

Beverloo, H. Berna ;

Kooy, Marinus van Marwijk ;

Wijermans, Pierre W. ;

Biemond, Bart J. ;

Vellenga, Edo ;

Verdonck, Leo F. ;

Ossenkoppele, Gert J. ;

Lowenberg, Bob .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (17) :2140-2146

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