Avian-to-Human Receptor-Binding Adaptation by Influenza A Virus Hemagglutinin H4

被引：74

作者：

Song, Hao ^{[1
,2
]}

Qi, Jianxun ^{[2
]}

Xiao, Haixia ^{[3
,4
]}

Bi, Yuhai ^{[2
,4
]}

Zhang, Wei ^{[2
]}

Xu, Ying ^{[2
,5
]}

Wang, Fei ^{[2
]}

Shi, Yi ^{[2
,4
,6
]}

Gao, George F. ^{[1
,2
,3
,4
,5
,6
,7
]}

机构：

[1] Chinese Acad Sci, RNIH, Beijing Inst Life Sci, Beijing 100101, Peoples R China

[2] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China

[3] Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Lab Prot Engn & Vaccines, Tianjin 300308, Peoples R China

[4] Chinese Acad Sci, Ctr Influenza Res & Early Warning CASCIRE, Beijing 100101, Peoples R China

[5] Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China

[6] Univ Chinese Acad Sci, Savaid Med Sch, Beijing 101408, Peoples R China

[7] Chinese Ctr Dis Control & Prevent China CDC, Natl Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China

来源：

CELL REPORTS | 2017年 / 20卷 / 05期

基金：

中国国家自然科学基金;

关键词：

DOMESTIC DUCKS; GENETIC-CHARACTERIZATION; HUMAN INFECTION; TRANSMISSION; PATHOGENICITY; SPECIFICITY; EVOLUTION; SWINE;

D O I：

10.1016/j.celrep.2017.07.028

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Low-pathogenicity avian influenza viruses (LPAIVs) have caused a global concern to public health since the first novel LPAIV H7N9 outbreak occurred. The receptor-binding properties of the viral hemagglutinin are one key factor for efficient transmission and infection in humans. Recent evidence shows that H4 subtype viruses have been widely circulating in domestic poultry and human asymptomatic infections might have occurred. Here, we evaluated the receptor-binding properties of two representative isolates, avian H4N6 (containing Q226 and G228) and swine H4N6 (containing L226 and S228), and found that the avian isolate preferentially binds to avian receptors, whereas the swine isolate preferentially binds to human receptors. The Q226L and G228S substitutions are pivotal for the receptor-binding switch, which resulted in similar human receptor-binding features to the pandemic H2 and H3, implying that H4 has the potential to cause human infections. This early-warning study calls for future extensive surveillance.

引用

页码：1201 / 1214

页数：14

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