Alzheimer's disease and Type 2 diabetes mellitus: the cholinesterase connection?

被引：52
作者：
Allam, Appa Rao
Sridhar, Gumpeny Ramachandra [1 ]
Thota, Hanuman
Babu, Changalasetty Suresh
Prasad, Akula Siva
Divakar, Ch
机构：
[1] Andhra Univ, Dept Comp Sci & Syst Engn, Visakhapatnam 530003, Andhra Pradesh, India
[2] Endocrine & Diabet Ctr, Visakhapatnam 530002, Andhra Pradesh, India
[3] Acharya Nagarjuna Univ, Dept Comp Sci, Guntur, India
[4] Gandhi Inst Technol & Management, Dept Comp Sci, Visakhapatnam, Andhra Pradesh, India
来源：
LIPIDS IN HEALTH AND DISEASE | 2006年 / 5卷 / 1期
关键词：
D O I：
10.1186/1476-511X-5-28
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Alzheimer's disease and type 2 diabetes mellitus tend to occur together. We sought to identify protein(s) common to both conditions that could suggest a possible unifying pathogenic role. Using human neuronal butyrylcholinesterase (AAH08396.1) as the reference protein we used BLAST Tool for protein to protein comparison in humans. We found three groups of sequences among a series of 12, with an E-value between 0-12, common to both Alzheimer's disease and diabetes: butyrylcholinesterase precursor K allele (NP_000046.1), acetylcholinesterase isoform E4-E6 precursor (NP_000656.1), and apoptosis-related acetylcholinesterase (1B41 vertical bar A). Butyrylcholinesterase and acetylcholinesterase related proteins were found common to both Alzheimer's disease and diabetes; they may play an etiological role via influencing insulin resistance and lipid metabolism.
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页数：5
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