Blood Levels of Glycated Hemoglobin, D-Dimer, and Fibrinogen in Diabetic Retinopathy

被引:9
|
作者
Zhao, Heng [1 ]
Zhang, Li-Dan [2 ]
Liu, Li-Fang [1 ]
Li, Chun-Qing [3 ]
Song, Wei-Li [3 ]
Pang, Yong-Yang [1 ]
Zhang, Yun-Liang [1 ]
Li, Dan [4 ]
机构
[1] First Cent Hosp Baoding, Endocrinol Lab, Baoding 071000, Hebei, Peoples R China
[2] First Cent Hosp Baoding, Dept Nucl Med, Baoding 071000, Hebei, Peoples R China
[3] First Cent Hosp Baoding, Outpatient Dept, Baoding 071000, Hebei, Peoples R China
[4] Hebei Univ, Dept Ophthalmol, Affiliated Hosp, Baoding 071000, Hebei, Peoples R China
来源
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY | 2021年 / 14卷
关键词
glycated hemoglobin; HbA1c; D-dimer; D-D; fibrinogen; FIB; diabetic retinopathy; DR; microangiopathy; RISK-FACTORS;
D O I
10.2147/DMSO.S309068
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose: This study aimed to describe the levels of glycated hemoglobin (HbA1c), D-dimer (D-D), and fibrinogen (FIB) in different types of diabetic retinopathy (DR). Methods: A total of 61 patients with diabetes, who were treated in our department between November 2017 and May 2019, were selected. According to their non-mydriatic fundus photography and fundus angiography results, patients were divided into three groups, ie, the non-DR (NDR) group (n=23), the non-proliferative DR (NPDR) group (n=17), and the proliferative DR (PDR) group (n=21). A control group of 20 people who had tested negative for diabetes was also included. The levels of HbA1c, D-D, and FIB were measured and compared, respectively. Results: The mean values of HbA1c were 6.8% (5.2%, 7.7%), 7.4% (5.8%, 9.0%), and 8.5% (6.3%, 9.7%) in the NDR, NPDR, and PDR groups, respectively. The control group values were 4.9% (4.1%, 5.8%). These results indicated a significant statistical difference between groups. The mean values of D-D were 0.39 +/- 0.21 mg/L, 1.06 +/- 0.54 mg/L, and 1.39 +/- 0.59 mg/L in the NDR, NPDR, and PDR groups, respectively. The control group result was 0.36 +/- 0.17 mg/L. The values of the NPDR and PDR groups were significantly higher than those of the NDR and control groups, and the value of the PDR group was significantly higher than that of the NPDR group, indicating a significant difference between the groups (P < 0.001). The mean values of FIB were 3.07 +/- 0.42 g/L, 4.38 +/- 0.54 g/L, and 4.46 +/- 1.09 g/L in the NDR, NPDR, and PDR groups, respectively. The control group result was 2.97 +/- 0.67 g/L. The difference between the groups was statistically significant (P < 0.05). Conclusion: Blood levels of HbA1c, D-D, and FIB in the PDR group were significantly higher than in the NPDR group.
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页码:2483 / 2488
页数:6
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