A Cellular Potts Model of single cell migration in presence of durotaxis

被引：24

作者：

Allena, R. ^{[1
]}

Scianna, M. ^{[2
]}

Preziosi, L. ^{[2
]}

机构：

[1] Arts & Metiers ParisTech, LBM Inst Biomecan Humaine Georges Charpak, 151 Bd Hop, F-75013 Paris, France

[2] Politecn Torino, Dipartimento Sci Math, Corso Duca Abruzzi 24, I-10129 Turin, Italy

来源：

MATHEMATICAL BIOSCIENCES | 2016年 / 275卷

关键词：

Cell migration; Durotaxis; Cell polarity; Anisotropy; CPM; STIFFNESS GRADIENT STRENGTH; SUBSTRATE STIFFNESS; TRACTION FORCES; EXTRACELLULAR-MATRIX; MICROSCALE CONTROL; PATTERN-FORMATION; MULTISCALE MODEL; STEM-CELLS; IN-SILICO; GROWTH;

D O I：

10.1016/j.mbs.2016.02.011

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cell migration is a fundamental biological phenomenon during which cells sense their surroundings and respond to different types of signals. In presence of durotaxis, cells preferentially crawl from soft to stiff substrates by reorganizing their cytoskeleton from an isotropic to an anisotropic distribution of actin filaments. In the present paper, we propose a Cellular Potts Model to simulate single cell migration over flat substrates with variable stiffness. We have tested five configurations: (i) a substrate including a soft and a stiff region, (ii) a soft substrate including two parallel stiff stripes, (iii) a substrate made of successive stripes with increasing stiffness to create a gradient and (iv) a stiff substrate with four embedded soft squares. For each simulation, we have evaluated the morphology of the cell, the distance covered, the spreading area and the migration speed. We have then compared the numerical results to specific experimental observations showing a consistent agreement. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：57 / 70

页数：14

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