Mitochondrial biogenesis in mammals: The role of endogenous nitric oxide

被引：1010

作者：

Nisoli, E ^{[1
]}

Clementi, E

Paolucci, C

Cozzi, V

Tonello, C

Sciorati, C

Bracale, R

Valerio, A

Francolini, M

Moncada, S

Carruba, MO

机构：

[1] Univ Milan, L Sacco Hosp Vialba, Dept Preclin Sci, Ctr Study & Res Obes, I-20157 Milan, Italy

[2] Ist Auxol Italiano, I-20149 Milan, Italy

[3] Ist Sci San Raffaele, DIBIT H, I-20132 Milan, Italy

[4] Univ Calabria, Dept Pharmacobiol, I-87036 Arcavacata Di Rende, Italy

[5] Univ Brescia, Dept Biomed Sci & Biotechnol, I-25123 Brescia, Italy

[6] CNR, Inst Neurosci, Cellular & Mol Pharmacol Sect, I-20129 Milan, Italy

[7] UCL, Wolfson Inst Biomed Res, London WC1E 6BT, England

来源：

SCIENCE | 2003年 / 299卷 / 5608期

关键词：

D O I：

10.1126/science.1079368

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nitric oxide was found to trigger mitochondrial biogenesis in cells as diverse as brown adipocytes and 3T3-L1, U937, and HeLa cells. This effect of nitric oxide was dependent on guanosine 3',5'-monophosphate (cGMP) and was mediated by the induction of peroxisome proliferator-activated receptor gamma coactivator 1alpha, a master regulator of mitochondrial biogenesis. Moreover, the mitochondrial biogenesis induced by exposure to cold was markedly reduced in brown adipose tissue of endothelial nitric oxide synthase null-mutant (eNOS(-/-)) mice, which had a reduced metabolic rate and accelerated weight gain as compared to wild-type mice. Thus, a nitric oxide-cGMP-dependent pathway controls mitochondrial biogenesis and body energy balance.

引用

页码：896 / 899

页数：4

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