Gut Microbiota Promotes Tumor Growth in Mice by Modulating Immune Response

被引：309

作者：

Sethi, Vrishketan ^{[1
,2
]}

Kurtom, Saba ^{[1
,2
]}

Tarique, Mohammad ^{[1
,2
]}

Lavania, Shweta ^{[1
,2
]}

Malchiodi, Zoe ^{[1
,2
]}

Hellmund, Leonor ^{[1
,2
]}

Zhang, Li ^{[1
,2
]}

Sharma, Umakant ^{[1
,2
]}

Giri, Bhuwan ^{[1
,2
]}

Garg, Bharti ^{[1
,2
]}

Ferrantella, Anthony ^{[1
,2
]}

Vickers, Selwyn M. ^{[3
]}

Banerjee, Sulagna ^{[1
,2
]}

Dawra, Rajinder ^{[1
,2
]}

Roy, Sabita ^{[1
,2
]}

Ramakrishnan, Sundaram ^{[1
,2
]}

Saluja, Ashok ^{[1
,2
]}

Dudeja, Vikas ^{[1
,2
]}

机构：

[1] Sylvester Comprehens Canc Ctr, Dept Surg, Miami, FL USA

[2] Univ Miami, Miller Sch Med, Miami, FL 33136 USA

[3] Univ Alabama Birmingham, Dept Surg, Birmingham, AL 35294 USA

来源：

GASTROENTEROLOGY | 2018年 / 155卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Gut Bacteria; Immune Regulation; Tumor Promotion; Metastases; IL-17;

D O I：

10.1053/j.gastro.2018.04.001

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We studied the effects of gut microbiome depletion by oral antibiotics on tumor growth in subcutaneous and liver metastases models of pancreatic cancer, colon cancer, and melanoma. Gut microbiome depletion significantly reduced tumor burden in all the models tested. However, depletion of gut microbiome did not reduce tumor growth in Rag1-knockout mice, which lack mature T and B cells. Flow cytometry analyses demonstrated that gut microbiome depletion led to significant increase in interferon gamma-producing T cells with corresponding decrease in interleukin 17A and interleukin 10-producing T cells. Our results suggest that gut microbiome modulation could emerge as a novel immunotherapeutic strategy.

引用

页码：33 / +

页数：11

共 14 条

[11] Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: Antibiotics, probiotics, and prebiotics [J].